Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 76974..77499 | Replicon | plasmid pSDU1-USMARC-69838 |
| Accession | NZ_CP032450 | ||
| Organism | Salmonella enterica subsp. enterica serovar Dublin strain USMARC-69838 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | I3W3D5 |
| Locus tag | DZA56_RS25695 | Protein ID | WP_001159863.1 |
| Coordinates | 77194..77499 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7S5D0 |
| Locus tag | DZA56_RS25690 | Protein ID | WP_000813641.1 |
| Coordinates | 76974..77192 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DZA56_RS25645 | 72001..72714 | + | 714 | WP_000801115.1 | hypothetical protein | - |
| DZA56_RS25655 | 72839..73423 | + | 585 | WP_001575501.1 | hypothetical protein | - |
| DZA56_RS25660 | 73496..73708 | + | 213 | WP_000063794.1 | hypothetical protein | - |
| DZA56_RS26180 | 73969..74130 | + | 162 | WP_001816720.1 | hypothetical protein | - |
| DZA56_RS25665 | 74156..75004 | + | 849 | WP_000175391.1 | SdiA-regulated domain-containing protein | - |
| DZA56_RS25680 | 75574..76002 | - | 429 | WP_000812999.1 | type II toxin-antitoxin system VapC family toxin | - |
| DZA56_RS25685 | 75999..76229 | - | 231 | WP_001261283.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| DZA56_RS25690 | 76974..77192 | + | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| DZA56_RS25695 | 77194..77499 | + | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| DZA56_RS25700 | 77501..77791 | + | 291 | WP_001266176.1 | hypothetical protein | - |
| DZA56_RS25705 | 77788..78309 | + | 522 | WP_000198608.1 | hypothetical protein | - |
| DZA56_RS25710 | 78344..79126 | + | 783 | WP_000082169.1 | site-specific integrase | - |
| DZA56_RS25715 | 79135..79847 | + | 713 | Protein_96 | EAL domain-containing protein | - |
| DZA56_RS25720 | 79851..80360 | + | 510 | WP_001541544.1 | CaiF/GrlA family transcriptional regulator | - |
| DZA56_RS25725 | 80354..80690 | + | 337 | Protein_98 | hypothetical protein | - |
| DZA56_RS25730 | 80902..81462 | + | 561 | WP_000900095.1 | inverse autotransporter beta domain-containing protein | - |
| DZA56_RS25735 | 81529..81888 | - | 360 | WP_001675600.1 | helix-turn-helix domain-containing protein | - |
| DZA56_RS25740 | 81945..82370 | + | 426 | WP_000064919.1 | IS200/IS605 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..114923 | 114923 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 13091.77 Da Isoelectric Point: 12.8043
>T111804 WP_001159863.1 NZ_CP032450:77194-77499 [Salmonella enterica subsp. enterica serovar Dublin]
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Download Length: 306 bp
>T111804 NZ_CP032450:77194-77499 [Salmonella enterica subsp. enterica serovar Dublin]
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Antitoxin
Download Length: 73 a.a. Molecular weight: 9374.72 Da Isoelectric Point: 12.6573
>AT111804 WP_000813641.1 NZ_CP032450:76974-77192 [Salmonella enterica subsp. enterica serovar Dublin]
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Download Length: 219 bp
>AT111804 NZ_CP032450:76974-77192 [Salmonella enterica subsp. enterica serovar Dublin]
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Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | I3W3D5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656ICA6 |