Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 75574..76229 Replicon plasmid pSDU1-USMARC-69838
Accession NZ_CP032450
Organism Salmonella enterica subsp. enterica serovar Dublin strain USMARC-69838

Toxin (Protein)


Gene name vagD Uniprot ID M7RF18
Locus tag DZA56_RS25680 Protein ID WP_000812999.1
Coordinates 75574..76002 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID H9AC95
Locus tag DZA56_RS25685 Protein ID WP_001261283.1
Coordinates 75999..76229 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DZA56_RS25635 70975..71739 + 765 WP_000827659.1 K88 minor fimbrial subunit faeI -
DZA56_RS25640 71726..72001 + 276 WP_001020576.1 hypothetical protein -
DZA56_RS25645 72001..72714 + 714 WP_000801115.1 hypothetical protein -
DZA56_RS25655 72839..73423 + 585 WP_001575501.1 hypothetical protein -
DZA56_RS25660 73496..73708 + 213 WP_000063794.1 hypothetical protein -
DZA56_RS26180 73969..74130 + 162 WP_001816720.1 hypothetical protein -
DZA56_RS25665 74156..75004 + 849 WP_000175391.1 SdiA-regulated domain-containing protein -
DZA56_RS25680 75574..76002 - 429 WP_000812999.1 type II toxin-antitoxin system VapC family toxin Toxin
DZA56_RS25685 75999..76229 - 231 WP_001261283.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DZA56_RS25690 76974..77192 + 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA -
DZA56_RS25695 77194..77499 + 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB -
DZA56_RS25700 77501..77791 + 291 WP_001266176.1 hypothetical protein -
DZA56_RS25705 77788..78309 + 522 WP_000198608.1 hypothetical protein -
DZA56_RS25710 78344..79126 + 783 WP_000082169.1 site-specific integrase -
DZA56_RS25715 79135..79847 + 713 Protein_96 EAL domain-containing protein -
DZA56_RS25720 79851..80360 + 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
DZA56_RS25725 80354..80690 + 337 Protein_98 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..114923 114923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(16-56)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 21064.27 Da        Isoelectric Point: 5.5500

>T111803 WP_000812999.1 NZ_CP032450:c76002-75574 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 429 bp

>T111803 NZ_CP032450:c76002-75574 [Salmonella enterica subsp. enterica serovar Dublin]
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Antitoxin


Download         Length: 77 a.a.        Molecular weight: 11350.61 Da        Isoelectric Point: 5.5500

>AT111803 WP_001261283.1 NZ_CP032450:c76229-75999 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 231 bp

>AT111803 NZ_CP032450:c76229-75999 [Salmonella enterica subsp. enterica serovar Dublin]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M7RF18

Antitoxin

Source ID Structure
AlphaFold DB A0A6X6R7C5

References