Detailed information of TA system TA111802

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 30050..30572
• Replicon: plasmid pSDU1-USMARC-69838
• Accession: NZ_CP032450
• Organism: Salmonella enterica subsp. enterica serovar Dublin strain USMARC-69838

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G3CAN5
• Locus tag: DZA56_RS25385
• Protein ID: WP_000220560.1
• Coordinates: 30291..30572 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: DZA56_RS25380
• Protein ID: WP_000121743.1
• Coordinates: 30050..30301 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DZA56_RS25340	25461..26081	+	621	WP_000864788.1	ParA family protein	-
DZA56_RS25345	26133..26363	+	231	WP_000051066.1	partitioning protein	-
DZA56_RS25360	27002..27355	-	354	WP_001675596.1	hypothetical protein	-
DZA56_RS25365	27492..27938	-	447	WP_001074381.1	hypothetical protein	-
DZA56_RS25370	27978..28814	-	837	WP_001575533.1	replication initiation protein	-
DZA56_RS25380	30050..30301	+	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
DZA56_RS25385	30291..30572	+	282	WP_000220560.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DZA56_RS25390	30718..31041	+	324	WP_001181909.1	hypothetical protein	-
DZA56_RS25395	31086..31331	+	246	WP_000356542.1	hypothetical protein	-
DZA56_RS25400	31321..31536	+	216	WP_001180117.1	hypothetical protein	-
DZA56_RS25405	31629..31958	+	330	WP_000866650.1	hypothetical protein	-
DZA56_RS25410	32001..32180	+	180	WP_001575529.1	hypothetical protein	-
DZA56_RS25415	32202..32399	+	198	WP_001675595.1	hypothetical protein	-
DZA56_RS25420	32412..32684	+	273	WP_000160399.1	hypothetical protein	-
DZA56_RS25430	33010..33555	+	546	WP_000757691.1	hypothetical protein	-
DZA56_RS25435	33558..34739	+	1182	WP_000539536.1	relaxase/mobilization nuclease domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..114923	114923

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 12066.38 Da
• Isoelectric Point: 12.7685

>T111802 WP_000220560.1 NZ_CP032450:30291-30572 [Salmonella enterica subsp. enterica serovar Dublin]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Nucleotide

• Length: 282 bp

>T111802 NZ_CP032450:30291-30572 [Salmonella enterica subsp. enterica serovar Dublin]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 10784.64 Da
• Isoelectric Point: 12.7191

>AT111802 WP_000121743.1 NZ_CP032450:30050-30301 [Salmonella enterica subsp. enterica serovar Dublin]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Nucleotide

• Length: 252 bp

>AT111802 NZ_CP032450:30050-30301 [Salmonella enterica subsp. enterica serovar Dublin]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: G3CAN5

Antitoxin

• AlphaFold DB: A0A3S5I301