Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 64843..65498 Replicon plasmid pSDU1-USMARC-69840
Accession NZ_CP032447
Organism Salmonella enterica subsp. enterica serovar Dublin strain USMARC-69840

Toxin (Protein)


Gene name vagD Uniprot ID M7RF18
Locus tag DZA57_RS25155 Protein ID WP_000812999.1
Coordinates 64843..65271 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID H9AC95
Locus tag DZA57_RS25160 Protein ID WP_001261283.1
Coordinates 65268..65498 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DZA57_RS25110 60244..61008 + 765 WP_000827659.1 K88 minor fimbrial subunit faeI -
DZA57_RS25115 60995..61270 + 276 WP_001020576.1 hypothetical protein -
DZA57_RS25120 61270..61983 + 714 WP_000801115.1 hypothetical protein -
DZA57_RS25130 62108..62692 + 585 WP_001575501.1 hypothetical protein -
DZA57_RS25135 62765..62977 + 213 WP_000063794.1 hypothetical protein -
DZA57_RS25935 63238..63399 + 162 WP_001816720.1 hypothetical protein -
DZA57_RS25140 63425..64273 + 849 WP_000175391.1 SdiA-regulated domain-containing protein -
DZA57_RS25155 64843..65271 - 429 WP_000812999.1 type II toxin-antitoxin system VapC family toxin Toxin
DZA57_RS25160 65268..65498 - 231 WP_001261283.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DZA57_RS25165 66243..66461 + 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA -
DZA57_RS25170 66463..66768 + 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB -
DZA57_RS25175 66770..67060 + 291 WP_001266176.1 hypothetical protein -
DZA57_RS25180 67057..67578 + 522 WP_000198608.1 hypothetical protein -
DZA57_RS25185 67613..68395 + 783 WP_000082169.1 site-specific integrase -
DZA57_RS25190 68404..69116 + 713 Protein_84 EAL domain-containing protein -
DZA57_RS25195 69120..69629 + 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
DZA57_RS25200 69623..69959 + 337 Protein_86 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..74560 74560


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 21064.27 Da        Isoelectric Point: 5.5500

>T111799 WP_000812999.1 NZ_CP032447:c65271-64843 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 429 bp

>T111799 NZ_CP032447:c65271-64843 [Salmonella enterica subsp. enterica serovar Dublin]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 11350.61 Da        Isoelectric Point: 5.5500

>AT111799 WP_001261283.1 NZ_CP032447:c65498-65268 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 231 bp

>AT111799 NZ_CP032447:c65498-65268 [Salmonella enterica subsp. enterica serovar Dublin]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M7RF18

Antitoxin

Source ID Structure
AlphaFold DB A0A6X6R7C5

References