Detailed information of TA system TA111798

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 19320..19842
• Replicon: plasmid pSDU1-USMARC-69840
• Accession: NZ_CP032447
• Organism: Salmonella enterica subsp. enterica serovar Dublin strain USMARC-69840

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G3CAN5
• Locus tag: DZA57_RS24860
• Protein ID: WP_000220560.1
• Coordinates: 19561..19842 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: DZA57_RS24855
• Protein ID: WP_000121743.1
• Coordinates: 19320..19571 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DZA57_RS24815	14731..15351	+	621	WP_000864788.1	ParA family protein	-
DZA57_RS24820	15403..15633	+	231	WP_000051066.1	partitioning protein	-
DZA57_RS24835	16272..16625	-	354	WP_001675596.1	hypothetical protein	-
DZA57_RS24840	16762..17208	-	447	WP_001074381.1	hypothetical protein	-
DZA57_RS24845	17248..18084	-	837	WP_001575533.1	replication initiation protein	-
DZA57_RS24855	19320..19571	+	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
DZA57_RS24860	19561..19842	+	282	WP_000220560.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DZA57_RS24865	19988..20311	+	324	WP_001181909.1	hypothetical protein	-
DZA57_RS24870	20356..20601	+	246	WP_000356542.1	hypothetical protein	-
DZA57_RS24875	20591..20806	+	216	WP_001180117.1	hypothetical protein	-
DZA57_RS24880	20899..21228	+	330	WP_000866650.1	hypothetical protein	-
DZA57_RS24885	21271..21450	+	180	WP_001575529.1	hypothetical protein	-
DZA57_RS24890	21472..21669	+	198	WP_001675595.1	hypothetical protein	-
DZA57_RS24895	21682..21954	+	273	WP_000160399.1	hypothetical protein	-
DZA57_RS24905	22280..22825	+	546	WP_000757691.1	hypothetical protein	-
DZA57_RS24910	22828..24009	+	1182	WP_000539536.1	relaxase/mobilization nuclease domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..74560	74560

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-122)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-38)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 12066.38 Da
• Isoelectric Point: 12.7685

>T111798 WP_000220560.1 NZ_CP032447:19561-19842 [Salmonella enterica subsp. enterica serovar Dublin]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Nucleotide

• Length: 282 bp

>T111798 NZ_CP032447:19561-19842 [Salmonella enterica subsp. enterica serovar Dublin]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 10784.64 Da
• Isoelectric Point: 12.7191

>AT111798 WP_000121743.1 NZ_CP032447:19320-19571 [Salmonella enterica subsp. enterica serovar Dublin]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Nucleotide

• Length: 252 bp

>AT111798 NZ_CP032447:19320-19571 [Salmonella enterica subsp. enterica serovar Dublin]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: G3CAN5

Antitoxin

• AlphaFold DB: A0A3S5I301