Detailed information of TA system TA111797

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1639320..1640005
• Replicon: chromosome
• Accession: NZ_CP032429
• Organism: Neisseria gonorrhoeae strain TFG-B2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q5F6D1
• Locus tag: TFGB2_RS09620
• Protein ID: WP_003689143.1
• Coordinates: 1639823..1640005 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q5F6D2
• Locus tag: TFGB2_RS09615
• Protein ID: WP_003691454.1
• Coordinates: 1639320..1639721 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TFGB2_RS09560	1634365..1634580	-	216	WP_003691538.1	hypothetical protein	-
TFGB2_RS09565	1634632..1635123	-	492	WP_003691537.1	siphovirus Gp157 family protein	-
TFGB2_RS09570	1635120..1635302	-	183	WP_003691535.1	hypothetical protein	-
TFGB2_RS09575	1635442..1636128	-	687	WP_012503754.1	hypothetical protein	-
TFGB2_RS09580	1636197..1636358	-	162	WP_003691530.1	hypothetical protein	-
TFGB2_RS09585	1636355..1636630	-	276	WP_003703838.1	hypothetical protein	-
TFGB2_RS09590	1636783..1637115	-	333	WP_003695500.1	hypothetical protein	-
TFGB2_RS09595	1637256..1637543	-	288	WP_050171272.1	hypothetical protein	-
TFGB2_RS09600	1637540..1638016	-	477	WP_002255718.1	hypothetical protein	-
TFGB2_RS09605	1638049..1638249	-	201	WP_047920804.1	hypothetical protein	-
TFGB2_RS09610	1638439..1639221	+	783	WP_003689146.1	hypothetical protein	-
TFGB2_RS09615	1639320..1639721	-	402	WP_003691454.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
TFGB2_RS09620	1639823..1640005	-	183	WP_003689143.1	type II toxin-antitoxin system HicA family toxin	Toxin
TFGB2_RS09625	1640175..1640993	-	819	WP_025455900.1	DUF3037 domain-containing protein	-
TFGB2_RS09630	1640990..1641688	-	699	WP_003689139.1	hypothetical protein	-
TFGB2_RS09640	1641927..1642637	-	711	WP_025455899.1	helix-turn-helix transcriptional regulator	-
TFGB2_RS09645	1642753..1642941	+	189	WP_003689136.1	helix-turn-helix domain-containing protein	-
TFGB2_RS13425	1643021..1643281	+	261	WP_165865284.1	hypothetical protein	-
TFGB2_RS09660	1643511..1643738	+	228	WP_003691442.1	helix-turn-helix domain-containing protein	-
TFGB2_RS09665	1643735..1644736	+	1002	Protein_1666	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1624138..1657605	33467

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6687.77 Da
• Isoelectric Point: 10.7235

>T111797 WP_003689143.1 NZ_CP032429:c1640005-1639823 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK

Nucleotide

• Length: 183 bp

>T111797 NZ_CP032429:c1640005-1639823 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14634.43 Da
• Isoelectric Point: 4.5457

>AT111797 WP_003691454.1 NZ_CP032429:c1639721-1639320 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA

Nucleotide

• Length: 402 bp

>AT111797 NZ_CP032429:c1639721-1639320 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTTACCATGAATCAGGCAT
AG

Structures

Toxin

• AlphaFold DB: Q5F6D1

Antitoxin

• AlphaFold DB: Q5F6D2