Detailed information of TA system TA111795

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 4520240..4520765
• Replicon: chromosome
• Accession: NZ_CP032427
• Organism: Streptomyces griseorubiginosus strain 3E-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A927L4F6
• Locus tag: DWG14_RS20190
• Protein ID: WP_045558184.1
• Coordinates: 4520240..4520503 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A101UCA9
• Locus tag: DWG14_RS20195
• Protein ID: WP_027734289.1
• Coordinates: 4520496..4520765 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DWG14_RS20170	4515439..4517076	-	1638	WP_120051500.1	polyamine aminopropyltransferase	-
DWG14_RS20175	4517185..4517709	-	525	WP_062025947.1	DUF2617 family protein	-
DWG14_RS20180	4518115..4518486	-	372	WP_062025946.1	hypothetical protein	-
DWG14_RS20185	4518616..4519809	+	1194	WP_120051501.1	pyridoxal phosphate-dependent aminotransferase	-
DWG14_RS20190	4520240..4520503	-	264	WP_045558184.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DWG14_RS20195	4520496..4520765	-	270	WP_027734289.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DWG14_RS20200	4520872..4521305	+	434	Protein_3945	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
DWG14_RS43470	4521837..4522025	+	189	WP_079075667.1	hypothetical protein	-
DWG14_RS20210	4522112..4522777	+	666	WP_079075666.1	ABC transporter ATP-binding protein	-
DWG14_RS20215	4522774..4525062	+	2289	WP_062025943.1	FtsX-like permease family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (7-58)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10048.48 Da
• Isoelectric Point: 8.5041

>T111795 WP_045558184.1 NZ_CP032427:c4520503-4520240 [Streptomyces griseorubiginosus]
VSEYRTVFRAEAQAELRKVPRDMALRILAKLTELESDPMGFNTTALVSQPDRRRLRVGDYRVIYTIDNGELVVWVVHVGH
RSTVYDT

Nucleotide

• Length: 264 bp

>T111795 NZ_CP032427:c4520503-4520240 [Streptomyces griseorubiginosus]
GTGAGTGAGTACCGCACCGTCTTCCGAGCCGAGGCTCAGGCCGAACTCCGCAAGGTCCCGCGAGACATGGCCCTTCGTAT
TCTGGCCAAGCTGACTGAGCTGGAGAGCGACCCGATGGGGTTCAACACCACGGCCCTCGTCTCCCAGCCCGACCGGCGCC
GCCTACGGGTGGGCGACTACCGCGTGATCTACACGATCGACAACGGCGAGCTGGTGGTGTGGGTTGTACACGTCGGGCAT
CGCTCCACCGTCTACGACACCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10366.84 Da
• Isoelectric Point: 4.7473

>AT111795 WP_027734289.1 NZ_CP032427:c4520765-4520496 [Streptomyces griseorubiginosus]
MTQPMPIESIRDVRAHLAEVVERADRDDVPTVITRRGKQVAAVVSIEVLRKYQEWEEREINRIIDERMTNPTPGIPIEDI
MRETLARSE

Nucleotide

• Length: 270 bp

>AT111795 NZ_CP032427:c4520765-4520496 [Streptomyces griseorubiginosus]
ATGACGCAGCCAATGCCCATAGAGTCCATCCGCGATGTCCGGGCACACCTGGCCGAGGTCGTGGAGCGAGCCGACCGGGA
CGACGTGCCTACCGTGATCACCCGGCGCGGCAAGCAAGTCGCCGCCGTGGTGTCCATCGAGGTGCTGCGCAAATACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGACCAACCCGACACCCGGCATCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCGCGCAGTGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A101UCA9