Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1986169..1987001 Replicon chromosome
Accession NZ_CP032426
Organism Escherichia coli strain SCEC020001

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0Q2Y5N3
Locus tag C7V21_RS10800 Protein ID WP_001514886.1
Coordinates 1986169..1986543 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9IW59
Locus tag C7V21_RS10805 Protein ID WP_001360327.1
Coordinates 1986633..1987001 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7V21_RS10765 1981685..1982158 + 474 WP_001105385.1 DNA gyrase inhibitor SbmC -
C7V21_RS10770 1982357..1983415 + 1059 WP_032181141.1 FUSC family protein -
C7V21_RS10775 1983587..1983916 + 330 WP_000450409.1 DUF496 family protein -
C7V21_RS25435 1984017..1984199 - 183 WP_032181276.1 ethanolamine utilization protein -
C7V21_RS10785 1984653..1985681 - 1029 Protein_1859 IS110 family transposase -
C7V21_RS10790 1985840..1985953 - 114 WP_001161660.1 DUF957 domain-containing protein -
C7V21_RS10795 1985966..1986172 - 207 WP_000976829.1 hypothetical protein -
C7V21_RS10800 1986169..1986543 - 375 WP_001514886.1 TA system toxin CbtA family protein Toxin
C7V21_RS10805 1986633..1987001 - 369 WP_001360327.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C7V21_RS10810 1987412..1988284 - 873 WP_001069760.1 GTPase family protein -
C7V21_RS10815 1988369..1989286 - 918 WP_053911471.1 hypothetical protein -
C7V21_RS10825 1990118..1990315 - 198 WP_001329788.1 hypothetical protein -
C7V21_RS10835 1990486..1991088 - 603 WP_000813456.1 hypothetical protein -
C7V21_RS10840 1991183..1991389 - 207 WP_000235212.1 helix-turn-helix domain-containing protein -
C7V21_RS10845 1991530..1991796 + 267 WP_001520375.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13930.91 Da        Isoelectric Point: 7.2909

>T111782 WP_001514886.1 NZ_CP032426:c1986543-1986169 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T111782 NZ_CP032426:c1986543-1986169 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.34 Da        Isoelectric Point: 5.9598

>AT111782 WP_001360327.1 NZ_CP032426:c1987001-1986633 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT111782 NZ_CP032426:c1987001-1986633 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q2Y5N3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9IW59

References