Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3546818..3548358 Replicon chromosome
Accession NZ_CP032415
Organism Shewanella algae strain VGH117

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag D3X10_RS16875 Protein ID WP_117199984.1
Coordinates 3547057..3548358 (+) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag D3X10_RS16870 Protein ID WP_107005150.1
Coordinates 3546818..3547054 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D3X10_RS16855 (D3X10_16915) 3542125..3543141 - 1017 WP_039034405.1 IS110 family transposase -
D3X10_RS16860 (D3X10_16920) 3543465..3544085 - 621 WP_117199987.1 hypothetical protein -
D3X10_RS16865 (D3X10_16925) 3544090..3546030 - 1941 WP_218655775.1 AAA family ATPase -
D3X10_RS16870 (D3X10_16930) 3546818..3547054 + 237 WP_107005150.1 helix-turn-helix domain-containing protein Antitoxin
D3X10_RS16875 (D3X10_16935) 3547057..3548358 + 1302 WP_117199984.1 HipA domain-containing protein Toxin
D3X10_RS16880 (D3X10_16940) 3548419..3549372 + 954 WP_162887852.1 tetratricopeptide repeat protein -
D3X10_RS16885 (D3X10_16945) 3549478..3550113 - 636 WP_117200912.1 peptide chain release factor H -
D3X10_RS16890 (D3X10_16950) 3550113..3551276 - 1164 WP_117199982.1 RNA ligase RtcB family protein -
D3X10_RS16895 (D3X10_16955) 3551703..3552050 - 348 WP_109248696.1 hypothetical protein -
D3X10_RS16900 (D3X10_16960) 3552389..3552823 - 435 WP_020442396.1 HNH endonuclease -
D3X10_RS16905 (D3X10_16965) 3552873..3553148 - 276 WP_045283442.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3542125..3543141 1016


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48482.26 Da        Isoelectric Point: 4.6831

>T111762 WP_117199984.1 NZ_CP032415:3547057-3548358 [Shewanella algae]
MSGAANLVLDMHLGDRIIGELSFDPATESFAVSYSQDWQQNGFPISPMIPLDGTGSSTQIAMFLGNLLPENRGLDYLIES
LGVSRGNTFALIRAIGLDTAGAVAFSPKGTELPQTAFREISDDEIILRLEDPELWPMEVWDGKPRLSVAGVQSKLNLFYN
GKQFGFGEGALSSTHILKFEKQRHLVINEFLTMRLAKSIAMNVANVEIRHFGQHKSLCVERFDRRYLPAEQRVLRRHIID
SCQALGFSVNKKYERNFGNGRDVRDIREGVSLPRLFALAEQCANPAAAKQDMLQWTLFNLLSGNADAHGKNYSFFMIPTG
MVPTPWYDLVCVALYEEFEQELAMAIDDEFDPDKIYAYQLAAFSEDIGLPRALVSNSLTRMATRISQEIDGVIAMLNGLD
NDEQAFVASYKAQLLARCERYLDIAPQINEMEL

Download         Length: 1302 bp

>T111762 NZ_CP032415:3547057-3548358 [Shewanella algae]
ATGAGTGGAGCAGCAAACCTTGTCTTGGATATGCATCTTGGTGATCGAATCATAGGTGAGTTGTCATTCGACCCCGCCAC
CGAGAGTTTTGCCGTCAGTTACAGCCAAGATTGGCAGCAAAACGGCTTTCCCATATCACCCATGATCCCTTTGGATGGCA
CAGGAAGCAGCACACAGATCGCCATGTTTCTCGGCAACCTGTTGCCTGAAAACAGGGGCTTGGATTACCTCATCGAATCT
CTCGGTGTATCCAGGGGCAATACCTTTGCCCTTATCCGAGCCATTGGCTTGGATACTGCCGGTGCTGTTGCCTTTTCTCC
CAAGGGGACTGAACTGCCACAGACGGCATTTCGAGAAATCAGTGATGATGAAATCATTTTGCGCCTGGAAGATCCTGAGC
TCTGGCCAATGGAGGTGTGGGATGGCAAGCCCAGGCTGTCGGTAGCCGGGGTACAGTCGAAACTGAATCTGTTCTACAAC
GGTAAGCAATTTGGTTTCGGTGAAGGTGCCTTATCATCGACCCATATCTTGAAGTTCGAAAAGCAGCGGCATTTAGTCAT
CAACGAGTTTCTCACTATGCGTTTGGCGAAGTCGATAGCCATGAATGTCGCGAATGTTGAGATCCGCCATTTTGGCCAGC
ACAAATCATTGTGTGTCGAACGCTTTGATCGTCGTTATTTGCCCGCTGAACAGCGGGTGCTGAGAAGGCATATTATCGAT
AGCTGCCAAGCCCTTGGCTTTAGTGTGAATAAGAAATACGAACGAAATTTTGGTAATGGCCGTGATGTCAGAGATATTCG
CGAAGGCGTGAGCCTGCCCAGGCTGTTTGCTCTTGCGGAGCAATGCGCTAATCCGGCGGCGGCCAAACAGGATATGCTGC
AGTGGACGCTGTTTAATCTACTGAGTGGCAACGCCGATGCTCATGGTAAAAACTACTCCTTCTTCATGATACCGACAGGT
ATGGTGCCTACGCCTTGGTATGACTTGGTTTGCGTGGCCTTGTATGAGGAATTTGAGCAAGAGCTGGCGATGGCGATTGA
TGATGAATTCGACCCAGACAAGATCTACGCCTATCAATTGGCCGCGTTCAGCGAGGATATAGGGTTACCCAGAGCCTTGG
TGAGCAACAGCCTAACCAGAATGGCGACCAGAATAAGCCAAGAAATAGACGGTGTTATCGCAATGCTCAATGGATTGGAT
AACGATGAGCAGGCGTTTGTGGCGAGCTACAAAGCACAGTTATTGGCAAGGTGTGAGCGCTATTTGGATATTGCGCCCCA
AATCAATGAGATGGAACTTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8515.08 Da        Isoelectric Point: 9.6887

>AT111762 WP_107005150.1 NZ_CP032415:3546818-3547054 [Shewanella algae]
MVSPLTPHSLGALIKARRKEAALTLDVAAMLCGVTKKTFIRVEKGEDVYISTVFKILDGLGIRLLAQPKPDVDSTGWY

Download         Length: 237 bp

>AT111762 NZ_CP032415:3546818-3547054 [Shewanella algae]
ATGGTCTCGCCATTAACTCCACATTCATTGGGCGCTTTAATTAAGGCCCGTAGAAAAGAAGCTGCACTCACTCTGGATGT
GGCGGCAATGCTTTGTGGTGTCACCAAGAAAACCTTCATCCGGGTCGAGAAGGGTGAAGATGTCTACATCTCTACTGTCT
TCAAGATACTCGATGGTTTGGGGATCCGTCTGCTGGCGCAGCCCAAGCCTGATGTTGATTCGACCGGGTGGTACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References