Detailed information of TA system TA111760

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 1737861..1739006
• Replicon: chromosome
• Accession: NZ_CP032415
• Organism: Shewanella algae strain VGH117

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: D3X10_RS08665
• Protein ID: WP_054744620.1
• Coordinates: 1737861..1738607 (-)
• Length: 249 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A7X5Z3H2
• Locus tag: D3X10_RS08670
• Protein ID: WP_025011540.1
• Coordinates: 1738644..1739006 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D3X10_RS08640 (D3X10_08705)	1733079..1733645	-	567	WP_025011535.1	phosphoribosyltransferase family protein	-
D3X10_RS08645 (D3X10_08710)	1734056..1734781	+	726	WP_096142385.1	basic amino acid ABC transporter substrate-binding protein	-
D3X10_RS08650 (D3X10_08715)	1734788..1735465	+	678	WP_044733837.1	amino acid ABC transporter permease	-
D3X10_RS08655 (D3X10_08720)	1735458..1736183	+	726	WP_025886969.1	amino acid ABC transporter ATP-binding protein	-
D3X10_RS08660 (D3X10_08725)	1736282..1737847	+	1566	WP_117200371.1	hypothetical protein	-
D3X10_RS08665 (D3X10_08730)	1737861..1738607	-	747	WP_054744620.1	RES family NAD+ phosphorylase	Toxin
D3X10_RS08670 (D3X10_08735)	1738644..1739006	-	363	WP_025011540.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
D3X10_RS08675 (D3X10_08740)	1739239..1739892	+	654	WP_025886967.1	oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB	-
D3X10_RS08680 (D3X10_08745)	1740023..1740664	+	642	WP_025011542.1	DNA-J related domain-containing protein	-
D3X10_RS08685 (D3X10_08750)	1740805..1741542	+	738	WP_045283713.1	DsbA family protein	-
D3X10_RS08690 (D3X10_08755)	1741614..1742939	-	1326	WP_117200970.1	IS4 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1741614..1742939	1325

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (55-205)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (69-118)

Sequences

Toxin

Protein

• Length: 249 a.a.
• Molecular weight: 28870.61 Da
• Isoelectric Point: 4.6112

>T111760 WP_054744620.1 NZ_CP032415:c1738607-1737861 [Shewanella algae]
MDFSALEPQDFFPRPYLGRGYRLVESQEEAATLSLVDDFDEQMLLESLLDEVKPPYRSGTEHLHYLLKTPFRYPPLRHGS
RFGSITMESFFYASESWQTCLAEVAYYRFVFMADMLEPYLEPLRSEHMLYSVDINARDCADLTLLQGQEVQQQLTHKSNY
TYTQAMGAWLLQQQAQMIRYTSARAEEGVNLALHDPLVLQSTEPQECEYWICQSSADKVAFSRRNSRSMPLTWFLKDFLQ
DGQLPRPA

Nucleotide

• Length: 747 bp

>T111760 NZ_CP032415:c1738607-1737861 [Shewanella algae]
ATGGATTTTAGCGCGTTAGAGCCGCAGGACTTTTTCCCTCGCCCTTACCTTGGCCGCGGTTATCGCCTGGTCGAGTCCCA
GGAAGAAGCCGCCACCCTGAGCCTGGTGGATGATTTTGACGAACAGATGCTGCTTGAGTCTCTGCTCGATGAGGTTAAAC
CGCCTTACCGAAGTGGAACAGAGCACTTGCATTATCTGCTCAAGACCCCGTTTCGTTATCCGCCGCTGCGCCATGGCTCG
CGCTTTGGCAGTATCACAATGGAAAGCTTCTTTTATGCCAGTGAATCCTGGCAGACCTGTTTGGCCGAAGTTGCTTACTA
TCGTTTTGTCTTTATGGCCGACATGCTGGAGCCTTATCTGGAGCCGCTGCGCTCTGAGCATATGCTGTACTCTGTGGATA
TCAATGCCCGCGATTGTGCCGACCTGACGCTATTGCAGGGGCAGGAAGTGCAGCAGCAACTGACTCACAAGTCGAACTAT
ACCTATACCCAGGCTATGGGGGCCTGGCTGCTGCAACAGCAGGCGCAGATGATCCGCTACACTTCGGCCAGAGCCGAAGA
GGGCGTTAACCTGGCGCTGCACGATCCTTTGGTGTTGCAATCAACCGAGCCGCAGGAGTGTGAATACTGGATCTGCCAAA
GCTCGGCCGACAAGGTGGCTTTCAGTCGTCGTAATAGCCGCAGCATGCCATTGACTTGGTTTTTAAAAGACTTTTTGCAG
GACGGGCAGTTGCCGCGTCCTGCCTGA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13125.14 Da
• Isoelectric Point: 10.4675

>AT111760 WP_025011540.1 NZ_CP032415:c1739006-1738644 [Shewanella algae]
MNTLEKANAAEVLFKAFSNACSELQLTQAEASRIIGVNPSTLSRNSGKGFKPDSKQGELQLQLIRLYRSLYAIAGGEKAF
MRHWLNSPNKALNGTPKTLLQTVVGLVSVNQYLDAMRGKV

Nucleotide

• Length: 363 bp

>AT111760 NZ_CP032415:c1739006-1738644 [Shewanella algae]
ATGAATACCCTAGAGAAAGCCAATGCAGCCGAGGTATTATTCAAGGCGTTTTCCAATGCTTGCAGCGAGTTACAACTTAC
CCAGGCCGAGGCCAGCCGTATCATAGGTGTTAATCCCAGCACCTTGAGCCGTAACAGCGGCAAGGGGTTTAAACCCGATT
CCAAGCAGGGGGAACTGCAGTTGCAGCTTATCCGCCTGTATCGCTCGTTGTATGCCATAGCGGGTGGTGAGAAAGCCTTT
ATGCGTCACTGGCTCAACAGCCCCAACAAGGCGCTGAATGGGACCCCCAAGACTTTATTGCAAACCGTGGTTGGCCTGGT
GAGTGTTAACCAATATCTGGATGCGATGCGAGGCAAGGTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7X5Z3H2