111749

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2303512..2304995 Replicon chromosome
Accession NZ_CP032405
Organism Rhizobium rosettiformans strain MAE2-X

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag D4A92_RS11035 Protein ID WP_203012967.1
Coordinates 2303512..2304774 (-) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag D4A92_RS11040 Protein ID WP_203012970.1
Coordinates 2304771..2304995 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D4A92_RS11020 2299054..2301285 + 2232 WP_203012960.1 iron ABC transporter permease -
D4A92_RS11025 2301282..2302340 + 1059 WP_203012962.1 ABC transporter ATP-binding protein -
D4A92_RS11030 2302376..2303179 + 804 WP_203012964.1 inositol monophosphatase family protein -
D4A92_RS11035 2303512..2304774 - 1263 WP_203012967.1 type II toxin-antitoxin system HipA family toxin Toxin
D4A92_RS11040 2304771..2304995 - 225 WP_203012970.1 helix-turn-helix transcriptional regulator Antitoxin
D4A92_RS11045 2305792..2306040 + 249 WP_203012973.1 hypothetical protein -
D4A92_RS11050 2306037..2306324 + 288 WP_203012976.1 DUF1488 family protein -
D4A92_RS11055 2306443..2306745 + 303 WP_203012978.1 hypothetical protein -
D4A92_RS11060 2306990..2307268 + 279 WP_203012980.1 hypothetical protein -
D4A92_RS11065 2307284..2307487 + 204 WP_006727798.1 hypothetical protein -
D4A92_RS11070 2307586..2309865 + 2280 WP_203012982.1 glycosyltransferase family 4 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(146-362)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-66)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 45895.81 Da        Isoelectric Point: 5.3758

>T111749 WP_203012967.1 NZ_CP032405:c2304774-2303512 [Rhizobium rosettiformans]
MSRVLDVYAKDRKAGELRQDSDASLTFTYDGDYLANDPVALSMSLPVREEPFLDRIARPFFSGLLPDEGARRRLAAALGI
SSGNAFGLLEVIGGECAGALSLVPPGQLPPASTTDDAEALDEKRLEEILSLLRQRPLLGGEADIRLSLAGAQDKLAVTVL
NGQILLPRGGRPTTHILKPFIEGLDGTVENEVFCMSLGRRLGLDVPAVSKAAAGKVDYFLVERYDRLTLEDGRIERLHQE
DFCQALSVPPELKYEEEGGPGISQCLQLIRQTTARPAAETLRFQRMLMFHYLIGNADAHAKNYALLYRGKAPDLAPMYDA
ICTAAYPRLSKKMAMALGGRSLPDTIQMEHWASLVPSNKAATRMLAGELVRMADAIGPEADALMEEMSENGTDHPILKTV
RKIIDTRCALVRRALEKPSL

Download         Length: 1263 bp

>T111749 NZ_CP032405:c2304774-2303512 [Rhizobium rosettiformans]
ATGAGCCGCGTGCTGGACGTCTACGCAAAAGATCGGAAGGCCGGCGAGCTTAGGCAGGATAGCGACGCCTCGCTTACCTT
TACTTATGACGGCGACTACCTCGCCAATGATCCGGTCGCATTGTCAATGTCGCTCCCGGTGAGGGAAGAGCCATTCCTCG
ATCGAATCGCCCGCCCCTTCTTCTCTGGACTCCTGCCTGATGAAGGCGCCAGGCGTCGATTGGCTGCAGCACTGGGCATA
TCCTCAGGCAACGCCTTCGGGCTGCTGGAGGTTATCGGTGGGGAATGCGCGGGTGCCTTGTCGCTTGTTCCACCAGGACA
ACTCCCGCCGGCCTCGACGACAGACGATGCCGAAGCACTCGATGAGAAGCGCCTGGAAGAGATCCTCTCCCTGCTCAGAC
AGAGGCCCTTGCTCGGCGGGGAAGCGGACATACGCCTTTCGCTTGCCGGCGCTCAGGACAAGCTGGCTGTCACCGTTCTC
AACGGTCAGATATTGCTGCCGCGAGGCGGGCGCCCGACGACGCATATCCTGAAACCGTTCATCGAGGGCCTCGACGGCAC
GGTGGAGAACGAAGTGTTCTGCATGAGCCTGGGACGTCGTCTCGGCCTCGATGTCCCCGCTGTGTCGAAGGCCGCAGCCG
GCAAGGTCGATTACTTCCTGGTCGAGCGCTACGATCGGCTGACGCTTGAAGACGGGCGGATCGAGCGGCTGCACCAGGAA
GACTTCTGCCAGGCGCTGAGCGTGCCTCCGGAGCTCAAGTATGAGGAAGAGGGTGGCCCCGGCATCAGTCAGTGCCTCCA
GCTGATCCGACAGACGACGGCCAGGCCCGCGGCCGAGACATTGCGCTTCCAGCGAATGCTGATGTTCCACTACCTGATTG
GCAATGCCGACGCCCATGCCAAGAATTATGCCCTGCTCTATCGTGGGAAGGCGCCGGACCTGGCACCGATGTATGACGCT
ATTTGCACGGCTGCCTATCCACGACTGTCAAAGAAGATGGCGATGGCTCTCGGCGGCAGGTCACTGCCGGATACGATCCA
GATGGAACACTGGGCATCGCTCGTGCCGTCCAACAAGGCTGCAACGCGTATGCTGGCCGGCGAATTGGTCCGCATGGCAG
ACGCGATCGGGCCGGAAGCCGATGCGCTGATGGAAGAGATGTCCGAGAATGGCACTGACCACCCGATCTTGAAGACCGTC
CGAAAGATCATCGACACCAGATGCGCCCTGGTCAGAAGGGCGCTGGAGAAGCCTAGCCTGTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7800.93 Da        Isoelectric Point: 10.7087

>AT111749 WP_203012970.1 NZ_CP032405:c2304995-2304771 [Rhizobium rosettiformans]
MSTISDSAALGQLIRAERKRQQLTQEQLAGVAGVGVRFVRELESGKESCRVGLALTVLQSLGLTVSITNRGASS

Download         Length: 225 bp

>AT111749 NZ_CP032405:c2304995-2304771 [Rhizobium rosettiformans]
ATGTCGACGATCTCTGACAGCGCAGCTCTCGGTCAGCTAATCCGCGCAGAGCGAAAGCGTCAGCAACTGACCCAGGAACA
GCTTGCTGGCGTCGCGGGCGTGGGCGTGCGGTTCGTGCGCGAACTGGAGAGCGGCAAGGAAAGCTGCCGTGTCGGACTTG
CTTTGACCGTCCTTCAGTCGCTCGGCTTGACCGTGAGCATCACCAACCGTGGAGCTTCCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References