Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1640645..1641330 | Replicon | chromosome |
| Accession | NZ_CP032398 | ||
| Organism | Neisseria gonorrhoeae strain TFG-A2 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q5F6D1 |
| Locus tag | TFGA2_RS09525 | Protein ID | WP_003689143.1 |
| Coordinates | 1641148..1641330 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q5F6D2 |
| Locus tag | TFGA2_RS09520 | Protein ID | WP_003691454.1 |
| Coordinates | 1640645..1641046 (-) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| TFGA2_RS09470 | 1635847..1636062 | - | 216 | WP_003691538.1 | hypothetical protein | - |
| TFGA2_RS09475 | 1636114..1636605 | - | 492 | WP_003691537.1 | siphovirus Gp157 family protein | - |
| TFGA2_RS09480 | 1636602..1636784 | - | 183 | WP_003691535.1 | hypothetical protein | - |
| TFGA2_RS09485 | 1636923..1637607 | - | 685 | Protein_1647 | hypothetical protein | - |
| TFGA2_RS09495 | 1637833..1638108 | - | 276 | WP_003703838.1 | hypothetical protein | - |
| TFGA2_RS09500 | 1638260..1638592 | - | 333 | WP_003695500.1 | hypothetical protein | - |
| TFGA2_RS13355 | 1638733..1638870 | - | 138 | WP_187357179.1 | hypothetical protein | - |
| TFGA2_RS09505 | 1638867..1639343 | - | 477 | WP_002255718.1 | hypothetical protein | - |
| TFGA2_RS09510 | 1639374..1639574 | - | 201 | WP_047920804.1 | hypothetical protein | - |
| TFGA2_RS09515 | 1639764..1640546 | + | 783 | WP_003689146.1 | hypothetical protein | - |
| TFGA2_RS09520 | 1640645..1641046 | - | 402 | WP_003691454.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| TFGA2_RS09525 | 1641148..1641330 | - | 183 | WP_003689143.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| TFGA2_RS09530 | 1641500..1642318 | - | 819 | WP_025455900.1 | DUF3037 domain-containing protein | - |
| TFGA2_RS09535 | 1642315..1643013 | - | 699 | WP_003689139.1 | hypothetical protein | - |
| TFGA2_RS09545 | 1643252..1643962 | - | 711 | WP_025455899.1 | helix-turn-helix transcriptional regulator | - |
| TFGA2_RS09550 | 1644078..1644266 | + | 189 | WP_003689136.1 | helix-turn-helix domain-containing protein | - |
| TFGA2_RS13360 | 1644346..1644606 | + | 261 | WP_165865284.1 | hypothetical protein | - |
| TFGA2_RS09565 | 1644839..1645066 | + | 228 | WP_003691442.1 | helix-turn-helix domain-containing protein | - |
| TFGA2_RS09570 | 1645063..1646067 | + | 1005 | WP_050172491.1 | helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1625620..1658930 | 33310 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6687.77 Da Isoelectric Point: 10.7235
>T111743 WP_003689143.1 NZ_CP032398:c1641330-1641148 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
Download Length: 183 bp
>T111743 NZ_CP032398:c1641330-1641148 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14634.43 Da Isoelectric Point: 4.5457
>AT111743 WP_003691454.1 NZ_CP032398:c1641046-1640645 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
Download Length: 402 bp
>AT111743 NZ_CP032398:c1641046-1640645 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTTACCATGAATCAGGCAT
AG
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTTACCATGAATCAGGCAT
AG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|