Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 655788..656443 Replicon chromosome
Accession NZ_CP032398
Organism Neisseria gonorrhoeae strain TFG-A2

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag TFGA2_RS03990 Protein ID WP_003691083.1
Coordinates 656024..656443 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag TFGA2_RS03985 Protein ID WP_003688410.1
Coordinates 655788..656024 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TFGA2_RS03945 650922..651209 + 288 WP_003688407.1 hypothetical protein -
TFGA2_RS03950 651281..652447 + 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
TFGA2_RS03955 652458..653348 + 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
TFGA2_RS03960 653731..654117 - 387 Protein_670 IS110 family transposase -
TFGA2_RS03970 654329..654757 + 429 WP_003701165.1 helix-turn-helix domain-containing protein -
TFGA2_RS03975 654762..655340 + 579 WP_003688041.1 IS3 family transposase -
TFGA2_RS03980 655385..655582 + 198 WP_033910354.1 IS3 family transposase -
TFGA2_RS03985 655788..656024 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
TFGA2_RS03990 656024..656443 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
TFGA2_RS03995 656592..658046 - 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
TFGA2_RS04000 658043..658744 - 702 WP_003688414.1 lactate utilization protein C -
TFGA2_RS04005 658741..659520 - 780 WP_003688416.1 (Fe-S)-binding protein -
TFGA2_RS04010 659668..661209 + 1542 WP_003688418.1 multidrug efflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T111742 WP_003691083.1 NZ_CP032398:656024-656443 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T111742 NZ_CP032398:656024-656443 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT111742 WP_003688410.1 NZ_CP032398:655788-656024 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT111742 NZ_CP032398:655788-656024 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References