Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 249504..250159 Replicon plasmid p22429
Accession NZ_CP032397
Organism Salmonella enterica subsp. enterica serovar Dublin strain CVM 22429

Toxin (Protein)


Gene name vagD Uniprot ID M7RF18
Locus tag D5G01_RS26430 Protein ID WP_000812999.1
Coordinates 249731..250159 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID H9AC95
Locus tag D5G01_RS26425 Protein ID WP_001261283.1
Coordinates 249504..249734 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D5G01_RS26385 245043..245379 - 337 Protein_266 hypothetical protein -
D5G01_RS26390 245373..245882 - 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
D5G01_RS26395 245886..246598 - 713 Protein_268 EAL domain-containing protein -
D5G01_RS26400 246607..247389 - 783 WP_000082169.1 site-specific integrase -
D5G01_RS26405 247424..247945 - 522 WP_000198608.1 hypothetical protein -
D5G01_RS26410 247942..248232 - 291 WP_001266176.1 hypothetical protein -
D5G01_RS26415 248234..248539 - 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB -
D5G01_RS26420 248541..248759 - 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA -
D5G01_RS26425 249504..249734 + 231 WP_001261283.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
D5G01_RS26430 249731..250159 + 429 WP_000812999.1 type II toxin-antitoxin system VapC family toxin Toxin
D5G01_RS26445 250729..251577 - 849 WP_000175391.1 SdiA-regulated domain-containing protein -
D5G01_RS27145 251603..251764 - 162 WP_001816720.1 hypothetical protein -
D5G01_RS26450 252025..252237 - 213 WP_000063794.1 hypothetical protein -
D5G01_RS26460 252782..252970 + 189 WP_000957857.1 hypothetical protein -
D5G01_RS26465 252980..254179 + 1200 WP_000948429.1 IS91 family transposase -
D5G01_RS26475 254616..254789 + 174 WP_001675604.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..329264 329264


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 18346.91 Da        Isoelectric Point: 12.9522

>T111741 WP_000812999.1 NZ_CP032397:249731-250159 [Salmonella enterica subsp. enterica serovar Dublin]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 429 bp

>T111741 NZ_CP032397:249731-250159 [Salmonella enterica subsp. enterica serovar Dublin]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9887.42 Da        Isoelectric Point: 12.6808

>AT111741 WP_001261283.1 NZ_CP032397:249504-249734 [Salmonella enterica subsp. enterica serovar Dublin]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 231 bp

>AT111741 NZ_CP032397:249504-249734 [Salmonella enterica subsp. enterica serovar Dublin]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M7RF18

Antitoxin

Source ID Structure
AlphaFold DB A0A6X6R7C5

References