Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 248234..248759 Replicon plasmid p22429
Accession NZ_CP032397
Organism Salmonella enterica subsp. enterica serovar Dublin strain CVM 22429

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag D5G01_RS26415 Protein ID WP_001159863.1
Coordinates 248234..248539 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag D5G01_RS26420 Protein ID WP_000813641.1
Coordinates 248541..248759 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D5G01_RS26370 243354..243779 - 426 WP_000064919.1 IS200/IS605 family transposase -
D5G01_RS26375 243836..244204 + 369 WP_001675946.1 helix-turn-helix domain-containing protein -
D5G01_RS26380 244271..244831 - 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -
D5G01_RS26385 245043..245379 - 337 Protein_266 hypothetical protein -
D5G01_RS26390 245373..245882 - 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
D5G01_RS26395 245886..246598 - 713 Protein_268 EAL domain-containing protein -
D5G01_RS26400 246607..247389 - 783 WP_000082169.1 site-specific integrase -
D5G01_RS26405 247424..247945 - 522 WP_000198608.1 hypothetical protein -
D5G01_RS26410 247942..248232 - 291 WP_001266176.1 hypothetical protein -
D5G01_RS26415 248234..248539 - 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
D5G01_RS26420 248541..248759 - 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
D5G01_RS26425 249504..249734 + 231 WP_001261283.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
D5G01_RS26430 249731..250159 + 429 WP_000812999.1 type II toxin-antitoxin system VapC family toxin -
D5G01_RS26445 250729..251577 - 849 WP_000175391.1 SdiA-regulated domain-containing protein -
D5G01_RS27145 251603..251764 - 162 WP_001816720.1 hypothetical protein -
D5G01_RS26450 252025..252237 - 213 WP_000063794.1 hypothetical protein -
D5G01_RS26460 252782..252970 + 189 WP_000957857.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..329264 329264


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T111740 WP_001159863.1 NZ_CP032397:c248539-248234 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T111740 NZ_CP032397:c248539-248234 [Salmonella enterica subsp. enterica serovar Dublin]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT111740 WP_000813641.1 NZ_CP032397:c248759-248541 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT111740 NZ_CP032397:c248759-248541 [Salmonella enterica subsp. enterica serovar Dublin]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References