Detailed information of TA system TA111739

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 218902..219424
• Replicon: plasmid p22429
• Accession: NZ_CP032397
• Organism: Salmonella enterica subsp. enterica serovar Dublin strain CVM 22429

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G3CAN5
• Locus tag: D5G01_RS26215
• Protein ID: WP_000220560.1
• Coordinates: 218902..219183 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: D5G01_RS26220
• Protein ID: WP_000121743.1
• Coordinates: 219173..219424 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5G01_RS26170	214547..214852	-	306	WP_001159868.1	type II toxin-antitoxin system toxin CcdB	-
D5G01_RS26175	214854..215072	-	219	WP_000813634.1	type II toxin-antitoxin system antitoxin CcdA	-
D5G01_RS26180	215640..215822	+	183	Protein_228	hypothetical protein	-
D5G01_RS26185	215994..217193	-	1200	WP_000948429.1	IS91 family transposase	-
D5G01_RS26190	217203..217391	-	189	WP_000957857.1	hypothetical protein	-
D5G01_RS26195	217516..217845	-	330	WP_000866650.1	hypothetical protein	-
D5G01_RS26200	217938..218153	-	216	WP_001180117.1	hypothetical protein	-
D5G01_RS26205	218143..218388	-	246	WP_000356542.1	hypothetical protein	-
D5G01_RS26210	218433..218756	-	324	WP_001181909.1	hypothetical protein	-
D5G01_RS26215	218902..219183	-	282	WP_000220560.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D5G01_RS26220	219173..219424	-	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
D5G01_RS26230	220660..221262	+	603	Protein_237	replication initiation protein	-
D5G01_RS26235	221429..222628	-	1200	WP_000948429.1	IS91 family transposase	-
D5G01_RS26240	222638..222826	-	189	WP_000957857.1	hypothetical protein	-
D5G01_RS26245	222942..223184	+	243	Protein_240	RepB family plasmid replication initiator protein	-
D5G01_RS26250	223224..223670	+	447	WP_001074381.1	hypothetical protein	-
D5G01_RS26255	223738..224160	+	423	WP_000202949.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..329264	329264

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 13852.62 Da
• Isoelectric Point: 5.5500

>T111739 WP_000220560.1 NZ_CP032397:c219183-218902 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Nucleotide

• Length: 282 bp

>T111739 NZ_CP032397:c219183-218902 [Salmonella enterica subsp. enterica serovar Dublin]
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Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 12380.85 Da
• Isoelectric Point: 5.5500

>AT111739 WP_000121743.1 NZ_CP032397:c219424-219173 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Nucleotide

• Length: 252 bp

>AT111739 NZ_CP032397:c219424-219173 [Salmonella enterica subsp. enterica serovar Dublin]
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Structures

Toxin

• AlphaFold DB: G3CAN5

Antitoxin

• AlphaFold DB: A0A3S5I301