Detailed information of TA system TA111738

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 214547..215072
• Replicon: plasmid p22429
• Accession: NZ_CP032397
• Organism: Salmonella enterica subsp. enterica serovar Dublin strain CVM 22429

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: V0SSI5
• Locus tag: D5G01_RS26170
• Protein ID: WP_001159868.1
• Coordinates: 214547..214852 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: S1PPD8
• Locus tag: D5G01_RS26175
• Protein ID: WP_000813634.1
• Coordinates: 214854..215072 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5G01_RS26155	210457..211623	-	1167	WP_000772446.1	plasmid-partitioning protein SopA	-
D5G01_RS26160	212211..212966	-	756	WP_000852146.1	replication initiation protein RepE	-
D5G01_RS26165	213740..214546	-	807	WP_000016982.1	site-specific integrase	-
D5G01_RS26170	214547..214852	-	306	WP_001159868.1	type II toxin-antitoxin system toxin CcdB	Toxin
D5G01_RS26175	214854..215072	-	219	WP_000813634.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
D5G01_RS26180	215640..215822	+	183	Protein_228	hypothetical protein	-
D5G01_RS26185	215994..217193	-	1200	WP_000948429.1	IS91 family transposase	-
D5G01_RS26190	217203..217391	-	189	WP_000957857.1	hypothetical protein	-
D5G01_RS26195	217516..217845	-	330	WP_000866650.1	hypothetical protein	-
D5G01_RS26200	217938..218153	-	216	WP_001180117.1	hypothetical protein	-
D5G01_RS26205	218143..218388	-	246	WP_000356542.1	hypothetical protein	-
D5G01_RS26210	218433..218756	-	324	WP_001181909.1	hypothetical protein	-
D5G01_RS26215	218902..219183	-	282	WP_000220560.1	type II toxin-antitoxin system RelE/ParE family toxin	-
D5G01_RS26220	219173..219424	-	252	WP_000121743.1	plasmid stabilization protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..329264	329264

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T111738 WP_001159868.1 NZ_CP032397:c214852-214547 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T111738 NZ_CP032397:c214852-214547 [Salmonella enterica subsp. enterica serovar Dublin]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT111738 WP_000813634.1 NZ_CP032397:c215072-214854 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT111738 NZ_CP032397:c215072-214854 [Salmonella enterica subsp. enterica serovar Dublin]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• PDB: 4VUB
• PDB: 2VUB
• PDB: 7EPI
• PDB: 7EPG
• PDB: 3VUB
• PDB: 1X75
• PDB: 1VUB
• PDB: 7EPJ
• PDB: 3HPW
• PDB: 3G7Z

Antitoxin

• PDB: 3TCJ
• PDB: 2H3A
• PDB: 2ADN
• PDB: 2ADL
• PDB: 3HPW
• PDB: 2H3C
• PDB: 3G7Z
• AlphaFold DB: A0A829CQY2