Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 84357..84882 Replicon plasmid p22453_1
Accession NZ_CP032395
Organism Salmonella enterica subsp. enterica serovar Dublin strain CVM 22453

Toxin (Protein)


Gene name ccdB Uniprot ID V0SSI5
Locus tag D5G00_RS25760 Protein ID WP_001159868.1
Coordinates 84357..84662 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1PPD8
Locus tag D5G00_RS25765 Protein ID WP_000813634.1
Coordinates 84664..84882 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D5G00_RS25745 80267..81433 - 1167 WP_000772446.1 plasmid-partitioning protein SopA -
D5G00_RS25750 82021..82776 - 756 WP_000852146.1 replication initiation protein RepE -
D5G00_RS25755 83550..84356 - 807 WP_000016982.1 site-specific integrase -
D5G00_RS25760 84357..84662 - 306 WP_001159868.1 type II toxin-antitoxin system toxin CcdB Toxin
D5G00_RS25765 84664..84882 - 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
D5G00_RS25770 85450..85962 + 513 WP_000151784.1 hypothetical protein -
D5G00_RS25775 85996..87129 - 1134 WP_000545987.1 DUF3800 domain-containing protein -
D5G00_RS25780 87296..88069 - 774 WP_000905949.1 hypothetical protein -
D5G00_RS25785 88082..88582 - 501 WP_000528931.1 hypothetical protein -
D5G00_RS25790 88847..89077 + 231 WP_001261278.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
D5G00_RS25795 89074..89490 + 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..164900 164900


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T111734 WP_001159868.1 NZ_CP032395:c84662-84357 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T111734 NZ_CP032395:c84662-84357 [Salmonella enterica subsp. enterica serovar Dublin]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT111734 WP_000813634.1 NZ_CP032395:c84882-84664 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT111734 NZ_CP032395:c84882-84664 [Salmonella enterica subsp. enterica serovar Dublin]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4VUB
PDB 2VUB
PDB 7EPI
PDB 7EPG
PDB 3VUB
PDB 1X75
PDB 1VUB
PDB 7EPJ
PDB 3HPW
PDB 3G7Z

Antitoxin

Source ID Structure
PDB 3TCJ
PDB 2H3A
PDB 2ADN
PDB 2ADL
PDB 3HPW
PDB 2H3C
PDB 3G7Z
AlphaFold DB A0A829CQY2

References