Detailed information of TA system TA111732

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 33740..34262
• Replicon: plasmid p22453_2
• Accession: NZ_CP032394
• Organism: Salmonella enterica subsp. enterica serovar Dublin strain CVM 22453

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G3CAN5
• Locus tag: D5G00_RS25050
• Protein ID: WP_000220560.1
• Coordinates: 33981..34262 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: D5G00_RS25045
• Protein ID: WP_000121743.1
• Coordinates: 33740..33991 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5G00_RS25005	29151..29771	+	621	WP_000864788.1	ParA family protein	-
D5G00_RS25010	29823..30053	+	231	WP_000051066.1	partitioning protein	-
D5G00_RS25025	30692..31114	-	423	WP_000202949.1	hypothetical protein	-
D5G00_RS25030	31182..31628	-	447	WP_001074381.1	hypothetical protein	-
D5G00_RS25035	31668..32504	-	837	WP_001575533.1	replication initiation protein	-
D5G00_RS25045	33740..33991	+	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
D5G00_RS25050	33981..34262	+	282	WP_000220560.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D5G00_RS25055	34408..34731	+	324	WP_001181909.1	hypothetical protein	-
D5G00_RS25060	34776..35021	+	246	WP_000356542.1	hypothetical protein	-
D5G00_RS25065	35011..35226	+	216	WP_001180117.1	hypothetical protein	-
D5G00_RS25070	35319..35648	+	330	WP_000866650.1	hypothetical protein	-
D5G00_RS25075	35691..35870	+	180	WP_001575529.1	hypothetical protein	-
D5G00_RS25080	35940..36089	+	150	WP_000003880.1	hypothetical protein	-
D5G00_RS25085	36102..36374	+	273	WP_000160399.1	hypothetical protein	-
D5G00_RS26590	36631..36705	+	75	Protein_48	DNA distortion polypeptide 3	-
D5G00_RS25095	36700..37245	+	546	WP_000757691.1	hypothetical protein	-
D5G00_RS25100	37248..38429	+	1182	WP_000539536.1	relaxase/mobilization nuclease domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..55415	55415

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (25-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (69-110)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 12066.38 Da
• Isoelectric Point: 12.7685

>T111732 WP_000220560.1 NZ_CP032394:33981-34262 [Salmonella enterica subsp. enterica serovar Dublin]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Nucleotide

• Length: 282 bp

>T111732 NZ_CP032394:33981-34262 [Salmonella enterica subsp. enterica serovar Dublin]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 10784.64 Da
• Isoelectric Point: 12.7191

>AT111732 WP_000121743.1 NZ_CP032394:33740-33991 [Salmonella enterica subsp. enterica serovar Dublin]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Nucleotide

• Length: 252 bp

>AT111732 NZ_CP032394:33740-33991 [Salmonella enterica subsp. enterica serovar Dublin]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: G3CAN5

Antitoxin

• AlphaFold DB: A0A3S5I301