Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 23849..24504 Replicon plasmid p22453_2
Accession NZ_CP032394
Organism Salmonella enterica subsp. enterica serovar Dublin strain CVM 22453

Toxin (Protein)


Gene name vagD Uniprot ID M7RF18
Locus tag D5G00_RS24960 Protein ID WP_000812999.1
Coordinates 23849..24277 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID H9AC95
Locus tag D5G00_RS24965 Protein ID WP_001261283.1
Coordinates 24274..24504 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D5G00_RS24915 19250..20014 + 765 WP_000827659.1 K88 minor fimbrial subunit faeI -
D5G00_RS24920 20001..20276 + 276 WP_001020576.1 hypothetical protein -
D5G00_RS24925 20276..20989 + 714 WP_000801115.1 hypothetical protein -
D5G00_RS24935 21114..21698 + 585 WP_001575501.1 hypothetical protein -
D5G00_RS24940 21771..21983 + 213 WP_000063794.1 hypothetical protein -
D5G00_RS26455 22244..22405 + 162 WP_001816720.1 hypothetical protein -
D5G00_RS24945 22431..23279 + 849 WP_000175391.1 SdiA-regulated domain-containing protein -
D5G00_RS24960 23849..24277 - 429 WP_000812999.1 type II toxin-antitoxin system VapC family toxin Toxin
D5G00_RS24965 24274..24504 - 231 WP_001261283.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
D5G00_RS24970 25249..25467 + 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA -
D5G00_RS24975 25469..25774 + 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB -
D5G00_RS24985 25844..26548 - 705 WP_001067858.1 IS6-like element IS26 family transposase -
D5G00_RS24990 26826..27161 + 336 WP_001527010.1 hypothetical protein -
D5G00_RS24995 27218..27784 + 567 WP_001541562.1 DUF2913 family protein -
D5G00_RS25000 27816..28758 - 943 Protein_33 Rpn family recombination-promoting nuclease/putative transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..55415 55415


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 21064.27 Da        Isoelectric Point: 5.5500

>T111730 WP_000812999.1 NZ_CP032394:c24277-23849 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 429 bp

>T111730 NZ_CP032394:c24277-23849 [Salmonella enterica subsp. enterica serovar Dublin]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 11350.61 Da        Isoelectric Point: 5.5500

>AT111730 WP_001261283.1 NZ_CP032394:c24504-24274 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 231 bp

>AT111730 NZ_CP032394:c24504-24274 [Salmonella enterica subsp. enterica serovar Dublin]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M7RF18

Antitoxin

Source ID Structure
AlphaFold DB A0A6X6R7C5

References