Detailed information of TA system TA111729

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 66310..66832
• Replicon: plasmid p34981_2
• Accession: NZ_CP032392
• Organism: Salmonella enterica subsp. enterica serovar Dublin strain CVM 34981

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G3CAN5
• Locus tag: D5F99_RS26135
• Protein ID: WP_000220560.1
• Coordinates: 66310..66591 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: D5F99_RS26140
• Protein ID: WP_000121743.1
• Coordinates: 66581..66832 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5F99_RS26085	62143..63324	-	1182	WP_000539536.1	relaxase/mobilization nuclease domain-containing protein	-
D5F99_RS26090	63327..63872	-	546	WP_000757691.1	hypothetical protein	-
D5F99_RS26460	63867..63941	-	75	Protein_74	DNA distortion polypeptide 3	-
D5F99_RS26100	64198..64470	-	273	WP_000160399.1	hypothetical protein	-
D5F99_RS26105	64483..64632	-	150	WP_000003880.1	hypothetical protein	-
D5F99_RS26110	64702..64881	-	180	WP_119768179.1	hypothetical protein	-
D5F99_RS26115	64924..65253	-	330	WP_000866650.1	hypothetical protein	-
D5F99_RS26120	65346..65561	-	216	WP_001180117.1	hypothetical protein	-
D5F99_RS26125	65551..65796	-	246	WP_000356542.1	hypothetical protein	-
D5F99_RS26130	65841..66164	-	324	WP_001181909.1	hypothetical protein	-
D5F99_RS26135	66310..66591	-	282	WP_000220560.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D5F99_RS26140	66581..66832	-	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
D5F99_RS26150	68068..68904	+	837	WP_001575533.1	replication initiation protein	-
D5F99_RS26155	68944..69390	+	447	WP_001074381.1	hypothetical protein	-
D5F99_RS26160	69458..69880	+	423	WP_000202949.1	hypothetical protein	-
D5F99_RS26175	70519..70749	-	231	WP_000051066.1	partitioning protein	-
D5F99_RS26180	70801..71421	-	621	WP_000864788.1	ParA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..74461	74461

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (27-113)

Antitoxin

• Cro/C1-type helix-turn-helix domain (44-91)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 13852.62 Da
• Isoelectric Point: 5.5500

>T111729 WP_000220560.1 NZ_CP032392:c66591-66310 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Nucleotide

• Length: 282 bp

>T111729 NZ_CP032392:c66591-66310 [Salmonella enterica subsp. enterica serovar Dublin]
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Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 12380.85 Da
• Isoelectric Point: 5.5500

>AT111729 WP_000121743.1 NZ_CP032392:c66832-66581 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Nucleotide

• Length: 252 bp

>AT111729 NZ_CP032392:c66832-66581 [Salmonella enterica subsp. enterica serovar Dublin]
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Structures

Toxin

• AlphaFold DB: G3CAN5

Antitoxin

• AlphaFold DB: A0A3S5I301