Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 19484..20009 | Replicon | plasmid p34981_2 |
| Accession | NZ_CP032392 | ||
| Organism | Salmonella enterica subsp. enterica serovar Dublin strain CVM 34981 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | I3W3D5 |
| Locus tag | D5F99_RS25825 | Protein ID | WP_001159863.1 |
| Coordinates | 19484..19789 (-) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7S5D0 |
| Locus tag | D5F99_RS25830 | Protein ID | WP_000813641.1 |
| Coordinates | 19791..20009 (-) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D5F99_RS25780 | 14613..15038 | - | 426 | WP_000064919.1 | IS200/IS605 family transposase | - |
| D5F99_RS25785 | 15095..15454 | + | 360 | WP_001675600.1 | helix-turn-helix domain-containing protein | - |
| D5F99_RS25790 | 15521..16081 | - | 561 | WP_000900095.1 | inverse autotransporter beta domain-containing protein | - |
| D5F99_RS25795 | 16293..16629 | - | 337 | Protein_17 | hypothetical protein | - |
| D5F99_RS25800 | 16623..17132 | - | 510 | WP_001541544.1 | CaiF/GrlA family transcriptional regulator | - |
| D5F99_RS25805 | 17136..17848 | - | 713 | Protein_19 | EAL domain-containing protein | - |
| D5F99_RS25810 | 17857..18639 | - | 783 | WP_000082169.1 | site-specific integrase | - |
| D5F99_RS25815 | 18674..19195 | - | 522 | WP_000198608.1 | hypothetical protein | - |
| D5F99_RS25820 | 19192..19482 | - | 291 | WP_001266176.1 | hypothetical protein | - |
| D5F99_RS25825 | 19484..19789 | - | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| D5F99_RS25830 | 19791..20009 | - | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| D5F99_RS25835 | 20754..20984 | + | 231 | WP_001261283.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| D5F99_RS25840 | 20981..21409 | + | 429 | WP_000812999.1 | type II toxin-antitoxin system VapC family toxin | - |
| D5F99_RS25855 | 21979..22827 | - | 849 | WP_000175391.1 | SdiA-regulated domain-containing protein | - |
| D5F99_RS26385 | 22853..23014 | - | 162 | WP_001816720.1 | hypothetical protein | - |
| D5F99_RS25860 | 23275..23487 | - | 213 | WP_000063794.1 | hypothetical protein | - |
| D5F99_RS25865 | 23560..24144 | - | 585 | WP_001575501.1 | hypothetical protein | - |
| D5F99_RS25875 | 24269..24982 | - | 714 | WP_000801115.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..74461 | 74461 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 15030.03 Da Isoelectric Point: 5.5500
>T111727 WP_001159863.1 NZ_CP032392:c19789-19484 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF
Download Length: 306 bp
>T111727 NZ_CP032392:c19789-19484 [Salmonella enterica subsp. enterica serovar Dublin]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
Antitoxin
Download Length: 73 a.a. Molecular weight: 10761.91 Da Isoelectric Point: 5.5500
>AT111727 WP_000813641.1 NZ_CP032392:c20009-19791 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
Download Length: 219 bp
>AT111727 NZ_CP032392:c20009-19791 [Salmonella enterica subsp. enterica serovar Dublin]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | I3W3D5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656ICA6 |