Detailed information of TA system TA111725

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 10829..11351
• Replicon: plasmid pN45955_2
• Accession: NZ_CP032389
• Organism: Salmonella enterica subsp. enterica serovar Dublin strain CVM N45955

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G3CAN5
• Locus tag: D5F98_RS25710
• Protein ID: WP_000220560.1
• Coordinates: 11070..11351 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: D5F98_RS25705
• Protein ID: WP_000121743.1
• Coordinates: 10829..11080 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5F98_RS25665	6240..6860	+	621	WP_000864788.1	ParA family protein	-
D5F98_RS25670	6912..7142	+	231	WP_000051066.1	partitioning protein	-
D5F98_RS25685	7781..8203	-	423	WP_000202949.1	hypothetical protein	-
D5F98_RS25690	8271..8717	-	447	WP_001074381.1	hypothetical protein	-
D5F98_RS25695	8757..9593	-	837	WP_001575533.1	replication initiation protein	-
D5F98_RS25705	10829..11080	+	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
D5F98_RS25710	11070..11351	+	282	WP_000220560.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D5F98_RS25715	11497..11820	+	324	WP_001181909.1	hypothetical protein	-
D5F98_RS25720	11865..12110	+	246	WP_000356542.1	hypothetical protein	-
D5F98_RS25725	12100..12315	+	216	WP_001180117.1	hypothetical protein	-
D5F98_RS25730	12408..12737	+	330	WP_000866650.1	hypothetical protein	-
D5F98_RS25735	12780..12959	+	180	WP_001575529.1	hypothetical protein	-
D5F98_RS25740	12981..13178	+	198	WP_001675595.1	hypothetical protein	-
D5F98_RS25745	13191..13463	+	273	WP_000160399.1	hypothetical protein	-
D5F98_RS26110	13720..13794	+	75	Protein_21	DNA distortion polypeptide 3	-
D5F98_RS25755	13789..14334	+	546	WP_000757691.1	hypothetical protein	-
D5F98_RS25760	14337..15518	+	1182	WP_000539536.1	relaxase/mobilization nuclease domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..36009	36009

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (2-44)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 12066.38 Da
• Isoelectric Point: 12.7685

>T111725 WP_000220560.1 NZ_CP032389:11070-11351 [Salmonella enterica subsp. enterica serovar Dublin]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Nucleotide

• Length: 282 bp

>T111725 NZ_CP032389:11070-11351 [Salmonella enterica subsp. enterica serovar Dublin]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 10784.64 Da
• Isoelectric Point: 12.7191

>AT111725 WP_000121743.1 NZ_CP032389:10829-11080 [Salmonella enterica subsp. enterica serovar Dublin]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Nucleotide

• Length: 252 bp

>AT111725 NZ_CP032389:10829-11080 [Salmonella enterica subsp. enterica serovar Dublin]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: G3CAN5

Antitoxin

• AlphaFold DB: A0A3S5I301