Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 50766..51291 | Replicon | plasmid pN45955_1 |
| Accession | NZ_CP032388 | ||
| Organism | Salmonella enterica subsp. enterica serovar Dublin strain CVM N45955 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | I3W3D5 |
| Locus tag | D5F98_RS25100 | Protein ID | WP_001159863.1 |
| Coordinates | 50986..51291 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7S5D0 |
| Locus tag | D5F98_RS25095 | Protein ID | WP_000813641.1 |
| Coordinates | 50766..50984 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D5F98_RS25050 | 45793..46506 | + | 714 | WP_000801115.1 | hypothetical protein | - |
| D5F98_RS25060 | 46631..47215 | + | 585 | WP_001575501.1 | hypothetical protein | - |
| D5F98_RS25065 | 47288..47500 | + | 213 | WP_000063794.1 | hypothetical protein | - |
| D5F98_RS26010 | 47761..47922 | + | 162 | WP_001816720.1 | hypothetical protein | - |
| D5F98_RS25070 | 47948..48796 | + | 849 | WP_000175391.1 | SdiA-regulated domain-containing protein | - |
| D5F98_RS25085 | 49366..49794 | - | 429 | WP_000812999.1 | type II toxin-antitoxin system VapC family toxin | - |
| D5F98_RS25090 | 49791..50021 | - | 231 | WP_001261283.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| D5F98_RS25095 | 50766..50984 | + | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| D5F98_RS25100 | 50986..51291 | + | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| D5F98_RS25105 | 51293..51583 | + | 291 | WP_001266176.1 | hypothetical protein | - |
| D5F98_RS25110 | 51580..52101 | + | 522 | WP_000198608.1 | hypothetical protein | - |
| D5F98_RS25115 | 52136..52918 | + | 783 | WP_000082169.1 | site-specific integrase | - |
| D5F98_RS25120 | 52927..53639 | + | 713 | Protein_64 | EAL domain-containing protein | - |
| D5F98_RS25125 | 53643..54152 | + | 510 | WP_001541544.1 | CaiF/GrlA family transcriptional regulator | - |
| D5F98_RS25130 | 54146..54482 | + | 337 | Protein_66 | hypothetical protein | - |
| D5F98_RS25135 | 54694..55254 | + | 561 | WP_000900095.1 | inverse autotransporter beta domain-containing protein | - |
| D5F98_RS25140 | 55321..55680 | - | 360 | WP_001675600.1 | helix-turn-helix domain-containing protein | - |
| D5F98_RS25145 | 55737..56162 | + | 426 | WP_000064919.1 | IS200/IS605 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..124532 | 124532 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 13091.77 Da Isoelectric Point: 12.8043
>T111723 WP_001159863.1 NZ_CP032388:50986-51291 [Salmonella enterica subsp. enterica serovar Dublin]
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Download Length: 306 bp
>T111723 NZ_CP032388:50986-51291 [Salmonella enterica subsp. enterica serovar Dublin]
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Antitoxin
Download Length: 73 a.a. Molecular weight: 9374.72 Da Isoelectric Point: 12.6573
>AT111723 WP_000813641.1 NZ_CP032388:50766-50984 [Salmonella enterica subsp. enterica serovar Dublin]
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Download Length: 219 bp
>AT111723 NZ_CP032388:50766-50984 [Salmonella enterica subsp. enterica serovar Dublin]
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Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | I3W3D5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656ICA6 |