Detailed information of TA system TA111721

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 40331..40853
• Replicon: plasmid pN53043_2
• Accession: NZ_CP032386
• Organism: Salmonella enterica subsp. enterica serovar Dublin strain CVM N53043

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G3CAN5
• Locus tag: D5F97_RS25920
• Protein ID: WP_000220560.1
• Coordinates: 40572..40853 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: D5F97_RS25915
• Protein ID: WP_000121743.1
• Coordinates: 40331..40582 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5F97_RS25875	35742..36362	+	621	WP_000864788.1	ParA family protein	-
D5F97_RS25880	36414..36644	+	231	WP_000051066.1	partitioning protein	-
D5F97_RS25895	37283..37705	-	423	WP_000202949.1	hypothetical protein	-
D5F97_RS25900	37773..38219	-	447	WP_001074381.1	hypothetical protein	-
D5F97_RS25905	38259..39095	-	837	WP_001575533.1	replication initiation protein	-
D5F97_RS25915	40331..40582	+	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
D5F97_RS25920	40572..40853	+	282	WP_000220560.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D5F97_RS25925	40999..41322	+	324	WP_001181909.1	hypothetical protein	-
D5F97_RS25930	41367..41612	+	246	WP_000356542.1	hypothetical protein	-
D5F97_RS25935	41602..41817	+	216	WP_001180117.1	hypothetical protein	-
D5F97_RS25940	41910..42239	+	330	WP_000866650.1	hypothetical protein	-
D5F97_RS25945	42282..42461	+	180	WP_001575529.1	hypothetical protein	-
D5F97_RS25950	42483..42680	+	198	WP_001675595.1	hypothetical protein	-
D5F97_RS25955	42693..42965	+	273	WP_000160399.1	hypothetical protein	-
D5F97_RS26410	43222..43296	+	75	Protein_60	DNA distortion polypeptide 3	-
D5F97_RS25965	43291..43836	+	546	WP_000757691.1	hypothetical protein	-
D5F97_RS25970	43839..45020	+	1182	WP_000539536.1	relaxase/mobilization nuclease domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..75390	75390

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 12066.38 Da
• Isoelectric Point: 12.7685

>T111721 WP_000220560.1 NZ_CP032386:40572-40853 [Salmonella enterica subsp. enterica serovar Dublin]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Nucleotide

• Length: 282 bp

>T111721 NZ_CP032386:40572-40853 [Salmonella enterica subsp. enterica serovar Dublin]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 10784.64 Da
• Isoelectric Point: 12.7191

>AT111721 WP_000121743.1 NZ_CP032386:40331-40582 [Salmonella enterica subsp. enterica serovar Dublin]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Nucleotide

• Length: 252 bp

>AT111721 NZ_CP032386:40331-40582 [Salmonella enterica subsp. enterica serovar Dublin]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: G3CAN5

Antitoxin

• AlphaFold DB: A0A3S5I301