Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 11865..12390 Replicon plasmid pN53043_2
Accession NZ_CP032386
Organism Salmonella enterica subsp. enterica serovar Dublin strain CVM N53043

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag D5F97_RS25730 Protein ID WP_001159863.1
Coordinates 12085..12390 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag D5F97_RS25725 Protein ID WP_000813641.1
Coordinates 11865..12083 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D5F97_RS25680 6892..7605 + 714 WP_000801115.1 hypothetical protein -
D5F97_RS25690 7730..8314 + 585 WP_001575501.1 hypothetical protein -
D5F97_RS25695 8387..8599 + 213 WP_000063794.1 hypothetical protein -
D5F97_RS26325 8860..9021 + 162 WP_001816720.1 hypothetical protein -
D5F97_RS25700 9047..9895 + 849 WP_000175391.1 SdiA-regulated domain-containing protein -
D5F97_RS25715 10465..10893 - 429 WP_000812999.1 type II toxin-antitoxin system VapC family toxin -
D5F97_RS25720 10890..11120 - 231 WP_001261283.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
D5F97_RS25725 11865..12083 + 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
D5F97_RS25730 12085..12390 + 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
D5F97_RS25735 12392..12682 + 291 WP_001266176.1 hypothetical protein -
D5F97_RS25740 12679..13200 + 522 WP_000198608.1 hypothetical protein -
D5F97_RS25745 13235..14017 + 783 WP_000082169.1 site-specific integrase -
D5F97_RS25750 14026..14738 + 713 Protein_21 EAL domain-containing protein -
D5F97_RS25755 14742..15251 + 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
D5F97_RS25760 15245..15581 + 337 Protein_23 hypothetical protein -
D5F97_RS25765 15793..16353 + 561 WP_119743387.1 inverse autotransporter beta domain-containing protein -
D5F97_RS25770 16420..16779 - 360 WP_001675600.1 helix-turn-helix domain-containing protein -
D5F97_RS25775 16836..17261 + 426 WP_000064919.1 IS200/IS605 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..75390 75390


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-134)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T111720 WP_001159863.1 NZ_CP032386:12085-12390 [Salmonella enterica subsp. enterica serovar Dublin]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T111720 NZ_CP032386:12085-12390 [Salmonella enterica subsp. enterica serovar Dublin]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT111720 WP_000813641.1 NZ_CP032386:11865-12083 [Salmonella enterica subsp. enterica serovar Dublin]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT111720 NZ_CP032386:11865-12083 [Salmonella enterica subsp. enterica serovar Dublin]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References