Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 10465..11120 Replicon plasmid pN53043_2
Accession NZ_CP032386
Organism Salmonella enterica subsp. enterica serovar Dublin strain CVM N53043

Toxin (Protein)


Gene name vagD Uniprot ID M7RF18
Locus tag D5F97_RS25715 Protein ID WP_000812999.1
Coordinates 10465..10893 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID H9AC95
Locus tag D5F97_RS25720 Protein ID WP_001261283.1
Coordinates 10890..11120 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D5F97_RS25670 5866..6630 + 765 WP_000827659.1 K88 minor fimbrial subunit faeI -
D5F97_RS25675 6617..6892 + 276 WP_001020576.1 hypothetical protein -
D5F97_RS25680 6892..7605 + 714 WP_000801115.1 hypothetical protein -
D5F97_RS25690 7730..8314 + 585 WP_001575501.1 hypothetical protein -
D5F97_RS25695 8387..8599 + 213 WP_000063794.1 hypothetical protein -
D5F97_RS26325 8860..9021 + 162 WP_001816720.1 hypothetical protein -
D5F97_RS25700 9047..9895 + 849 WP_000175391.1 SdiA-regulated domain-containing protein -
D5F97_RS25715 10465..10893 - 429 WP_000812999.1 type II toxin-antitoxin system VapC family toxin Toxin
D5F97_RS25720 10890..11120 - 231 WP_001261283.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
D5F97_RS25725 11865..12083 + 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA -
D5F97_RS25730 12085..12390 + 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB -
D5F97_RS25735 12392..12682 + 291 WP_001266176.1 hypothetical protein -
D5F97_RS25740 12679..13200 + 522 WP_000198608.1 hypothetical protein -
D5F97_RS25745 13235..14017 + 783 WP_000082169.1 site-specific integrase -
D5F97_RS25750 14026..14738 + 713 Protein_21 EAL domain-containing protein -
D5F97_RS25755 14742..15251 + 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
D5F97_RS25760 15245..15581 + 337 Protein_23 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..75390 75390


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 21064.27 Da        Isoelectric Point: 5.5500

>T111719 WP_000812999.1 NZ_CP032386:c10893-10465 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 429 bp

>T111719 NZ_CP032386:c10893-10465 [Salmonella enterica subsp. enterica serovar Dublin]
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Antitoxin


Download         Length: 77 a.a.        Molecular weight: 11350.61 Da        Isoelectric Point: 5.5500

>AT111719 WP_001261283.1 NZ_CP032386:c11120-10890 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 231 bp

>AT111719 NZ_CP032386:c11120-10890 [Salmonella enterica subsp. enterica serovar Dublin]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M7RF18

Antitoxin

Source ID Structure
AlphaFold DB A0A6X6R7C5

References