Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 39930..40585 Replicon plasmid pSDU2-USMARC-69807
Accession NZ_CP032381
Organism Salmonella enterica subsp. enterica serovar Dublin strain USMARC-69807

Toxin (Protein)


Gene name vagD Uniprot ID M7RF18
Locus tag DZA54_RS25715 Protein ID WP_000812999.1
Coordinates 40157..40585 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID H9AC95
Locus tag DZA54_RS25710 Protein ID WP_001261283.1
Coordinates 39930..40160 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DZA54_RS25670 35469..35805 - 337 Protein_45 hypothetical protein -
DZA54_RS25675 35799..36308 - 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
DZA54_RS25680 36312..37024 - 713 Protein_47 EAL domain-containing protein -
DZA54_RS25685 37033..37815 - 783 WP_000082169.1 site-specific integrase -
DZA54_RS25690 37850..38371 - 522 WP_000198608.1 hypothetical protein -
DZA54_RS25695 38368..38658 - 291 WP_001266176.1 hypothetical protein -
DZA54_RS25700 38660..38965 - 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB -
DZA54_RS25705 38967..39185 - 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA -
DZA54_RS25710 39930..40160 + 231 WP_001261283.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DZA54_RS25715 40157..40585 + 429 WP_000812999.1 type II toxin-antitoxin system VapC family toxin Toxin
DZA54_RS25730 41155..42003 - 849 WP_000175391.1 SdiA-regulated domain-containing protein -
DZA54_RS26110 42029..42190 - 162 WP_001816720.1 hypothetical protein -
DZA54_RS25735 42451..42663 - 213 WP_000063794.1 hypothetical protein -
DZA54_RS25740 42736..43320 - 585 WP_001575501.1 hypothetical protein -
DZA54_RS25750 43445..44158 - 714 WP_000801115.1 hypothetical protein -
DZA54_RS25755 44158..44433 - 276 WP_001020576.1 hypothetical protein -
DZA54_RS25760 44420..45184 - 765 WP_000827659.1 K88 minor fimbrial subunit faeI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..74562 74562


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 18346.91 Da        Isoelectric Point: 12.9522

>T111716 WP_000812999.1 NZ_CP032381:40157-40585 [Salmonella enterica subsp. enterica serovar Dublin]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 429 bp

>T111716 NZ_CP032381:40157-40585 [Salmonella enterica subsp. enterica serovar Dublin]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9887.42 Da        Isoelectric Point: 12.6808

>AT111716 WP_001261283.1 NZ_CP032381:39930-40160 [Salmonella enterica subsp. enterica serovar Dublin]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 231 bp

>AT111716 NZ_CP032381:39930-40160 [Salmonella enterica subsp. enterica serovar Dublin]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M7RF18

Antitoxin

Source ID Structure
AlphaFold DB A0A6X6R7C5

References