Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 38660..39185 | Replicon | plasmid pSDU2-USMARC-69807 |
| Accession | NZ_CP032381 | ||
| Organism | Salmonella enterica subsp. enterica serovar Dublin strain USMARC-69807 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | I3W3D5 |
| Locus tag | DZA54_RS25700 | Protein ID | WP_001159863.1 |
| Coordinates | 38660..38965 (-) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7S5D0 |
| Locus tag | DZA54_RS25705 | Protein ID | WP_000813641.1 |
| Coordinates | 38967..39185 (-) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DZA54_RS25655 | 33789..34214 | - | 426 | WP_000064919.1 | IS200/IS605 family transposase | - |
| DZA54_RS25660 | 34271..34630 | + | 360 | WP_001675600.1 | helix-turn-helix domain-containing protein | - |
| DZA54_RS25665 | 34697..35257 | - | 561 | WP_000900095.1 | inverse autotransporter beta domain-containing protein | - |
| DZA54_RS25670 | 35469..35805 | - | 337 | Protein_45 | hypothetical protein | - |
| DZA54_RS25675 | 35799..36308 | - | 510 | WP_001541544.1 | CaiF/GrlA family transcriptional regulator | - |
| DZA54_RS25680 | 36312..37024 | - | 713 | Protein_47 | EAL domain-containing protein | - |
| DZA54_RS25685 | 37033..37815 | - | 783 | WP_000082169.1 | site-specific integrase | - |
| DZA54_RS25690 | 37850..38371 | - | 522 | WP_000198608.1 | hypothetical protein | - |
| DZA54_RS25695 | 38368..38658 | - | 291 | WP_001266176.1 | hypothetical protein | - |
| DZA54_RS25700 | 38660..38965 | - | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| DZA54_RS25705 | 38967..39185 | - | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| DZA54_RS25710 | 39930..40160 | + | 231 | WP_001261283.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| DZA54_RS25715 | 40157..40585 | + | 429 | WP_000812999.1 | type II toxin-antitoxin system VapC family toxin | - |
| DZA54_RS25730 | 41155..42003 | - | 849 | WP_000175391.1 | SdiA-regulated domain-containing protein | - |
| DZA54_RS26110 | 42029..42190 | - | 162 | WP_001816720.1 | hypothetical protein | - |
| DZA54_RS25735 | 42451..42663 | - | 213 | WP_000063794.1 | hypothetical protein | - |
| DZA54_RS25740 | 42736..43320 | - | 585 | WP_001575501.1 | hypothetical protein | - |
| DZA54_RS25750 | 43445..44158 | - | 714 | WP_000801115.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..74562 | 74562 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 15030.03 Da Isoelectric Point: 5.5500
>T111715 WP_001159863.1 NZ_CP032381:c38965-38660 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
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FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF
Download Length: 306 bp
>T111715 NZ_CP032381:c38965-38660 [Salmonella enterica subsp. enterica serovar Dublin]
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Antitoxin
Download Length: 73 a.a. Molecular weight: 10761.91 Da Isoelectric Point: 5.5500
>AT111715 WP_000813641.1 NZ_CP032381:c39185-38967 [Salmonella enterica subsp. enterica serovar Dublin]
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Download Length: 219 bp
>AT111715 NZ_CP032381:c39185-38967 [Salmonella enterica subsp. enterica serovar Dublin]
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Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | I3W3D5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656ICA6 |