Detailed information of TA system TA111714

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 11025..11547
• Replicon: plasmid pSDU2-USMARC-69807
• Accession: NZ_CP032381
• Organism: Salmonella enterica subsp. enterica serovar Dublin strain USMARC-69807

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G3CAN5
• Locus tag: DZA54_RS25515
• Protein ID: WP_000220560.1
• Coordinates: 11025..11306 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: DZA54_RS25520
• Protein ID: WP_000121743.1
• Coordinates: 11296..11547 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DZA54_RS25465	6858..8039	-	1182	WP_000539536.1	relaxase/mobilization nuclease domain-containing protein	-
DZA54_RS25470	8042..8587	-	546	WP_000757691.1	hypothetical protein	-
DZA54_RS25480	8913..9185	-	273	WP_000160399.1	hypothetical protein	-
DZA54_RS25485	9198..9347	-	150	WP_000003880.1	hypothetical protein	-
DZA54_RS25490	9417..9596	-	180	WP_001575529.1	hypothetical protein	-
DZA54_RS25495	9639..9968	-	330	WP_000866650.1	hypothetical protein	-
DZA54_RS25500	10061..10276	-	216	WP_001180117.1	hypothetical protein	-
DZA54_RS25505	10266..10511	-	246	WP_000356542.1	hypothetical protein	-
DZA54_RS25510	10556..10879	-	324	WP_001181909.1	hypothetical protein	-
DZA54_RS25515	11025..11306	-	282	WP_000220560.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DZA54_RS25520	11296..11547	-	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
DZA54_RS25530	12783..13619	+	837	WP_001575533.1	replication initiation protein	-
DZA54_RS25535	13659..14105	+	447	WP_001074381.1	hypothetical protein	-
DZA54_RS25540	14242..14595	+	354	WP_001675596.1	hypothetical protein	-
DZA54_RS25555	15234..15464	-	231	WP_000051066.1	partitioning protein	-
DZA54_RS25560	15516..16136	-	621	WP_000864788.1	ParA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..74562	74562

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-126)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 13852.62 Da
• Isoelectric Point: 5.5500

>T111714 WP_000220560.1 NZ_CP032381:c11306-11025 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Nucleotide

• Length: 282 bp

>T111714 NZ_CP032381:c11306-11025 [Salmonella enterica subsp. enterica serovar Dublin]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 12380.85 Da
• Isoelectric Point: 5.5500

>AT111714 WP_000121743.1 NZ_CP032381:c11547-11296 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Nucleotide

• Length: 252 bp

>AT111714 NZ_CP032381:c11547-11296 [Salmonella enterica subsp. enterica serovar Dublin]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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Structures

Toxin

• AlphaFold DB: G3CAN5

Antitoxin

• AlphaFold DB: A0A3S5I301