Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2412997..2413972 | Replicon | chromosome |
| Accession | NZ_CP032365 | ||
| Organism | Bacillus wiedmannii strain SR52 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | A0A7V7LCP7 |
| Locus tag | D4A37_RS12280 | Protein ID | WP_074650800.1 |
| Coordinates | 2412997..2413734 (+) | Length | 246 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A150BES9 |
| Locus tag | D4A37_RS12285 | Protein ID | WP_000594607.1 |
| Coordinates | 2413847..2413972 (+) | Length | 42 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D4A37_RS12255 | 2408190..2408900 | + | 711 | WP_151035424.1 | class I SAM-dependent methyltransferase | - |
| D4A37_RS12260 | 2409019..2409426 | + | 408 | WP_000108375.1 | VOC family protein | - |
| D4A37_RS12265 | 2409476..2411152 | - | 1677 | WP_000842080.1 | alpha-keto acid decarboxylase family protein | - |
| D4A37_RS12270 | 2411269..2411751 | + | 483 | WP_000191898.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| D4A37_RS12275 | 2411924..2412661 | + | 738 | WP_000594134.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| D4A37_RS12280 | 2412997..2413734 | + | 738 | WP_074650800.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| D4A37_RS12285 | 2413847..2413972 | + | 126 | WP_000594607.1 | hypothetical protein | Antitoxin |
| D4A37_RS29530 | 2414048..2414224 | + | 177 | WP_000852622.1 | hypothetical protein | - |
| D4A37_RS12290 | 2414366..2415835 | + | 1470 | WP_000287561.1 | beta-Ala-His dipeptidase | - |
| D4A37_RS12295 | 2416420..2416890 | - | 471 | WP_033658763.1 | DUF5065 family protein | - |
| D4A37_RS12300 | 2417336..2417995 | + | 660 | WP_000682548.1 | CatB-related O-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 246 a.a. Molecular weight: 28385.06 Da Isoelectric Point: 8.3034
>T111712 WP_074650800.1 NZ_CP032365:2412997-2413734 [Bacillus wiedmannii]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAMFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPFEHIEQLNEQKAVQVENVGIIPAKTVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAMFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPFEHIEQLNEQKAVQVENVGIIPAKTVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
Download Length: 738 bp
>T111712 NZ_CP032365:2412997-2413734 [Bacillus wiedmannii]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTCGTTCTTGTGTTCTTTTACTGGAGAAACGA
AGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAACCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATCGCATTT
ATTTTGACACCTAATATTTCCGAAATATGGGGAGCGAAATTTAGCGATATCGGGAAGACTGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGGGAAATATATACAACAATTATTCAAAATGTCAATCCAGCAATGTTCGGTACAATGG
AATGGCATACGGAAGAAGAGTATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGTGCGAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACTAACTTTCGCGGTATCCGTTCTCAATTTAGTATTATCGTTCCGTTTGA
ACACATTGAGCAGTTGAATGAGCAGAAAGCGGTACAAGTAGAAAATGTCGGCATTATACCAGCAAAAACTGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAATCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTCGTTCTTGTGTTCTTTTACTGGAGAAACGA
AGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAACCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATCGCATTT
ATTTTGACACCTAATATTTCCGAAATATGGGGAGCGAAATTTAGCGATATCGGGAAGACTGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGGGAAATATATACAACAATTATTCAAAATGTCAATCCAGCAATGTTCGGTACAATGG
AATGGCATACGGAAGAAGAGTATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGTGCGAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACTAACTTTCGCGGTATCCGTTCTCAATTTAGTATTATCGTTCCGTTTGA
ACACATTGAGCAGTTGAATGAGCAGAAAGCGGTACAAGTAGAAAATGTCGGCATTATACCAGCAAAAACTGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAATCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
Antitoxin
Download Length: 42 a.a. Molecular weight: 4888.29 Da Isoelectric Point: 3.9798
>AT111712 WP_000594607.1 NZ_CP032365:2413847-2413972 [Bacillus wiedmannii]
VIKNNDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
VIKNNDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
Download Length: 126 bp
>AT111712 NZ_CP032365:2413847-2413972 [Bacillus wiedmannii]
GTGATTAAAAATAATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA
GTGATTAAAAATAATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7V7LCP7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A150BES9 |