111704

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3939383..3940658 Replicon chromosome
Accession NZ_CP032358
Organism Pseudomonas protegens strain pf5

Toxin (Protein)


Gene name vapC Uniprot ID Q4KD87
Locus tag D3X12_RS18520 Protein ID WP_011060985.1
Coordinates 3940059..3940658 (+) Length 200 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag D3X12_RS18515 Protein ID WP_011060984.1
Coordinates 3939383..3939940 (+) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D3X12_RS18485 3934587..3935237 + 651 WP_011060978.1 DUF2239 family protein -
D3X12_RS18490 3935325..3935945 + 621 WP_011060979.1 LysE family translocator -
D3X12_RS18495 3935991..3936578 - 588 WP_011060980.1 inclusion body family protein -
D3X12_RS18500 3937038..3938225 + 1188 WP_011060981.1 hypothetical protein -
D3X12_RS18505 3938404..3938814 - 411 WP_041774583.1 hypothetical protein -
D3X12_RS18510 3938852..3939193 - 342 WP_011060983.1 low molecular weight protein tyrosine phosphatase family protein -
D3X12_RS18515 3939383..3939940 + 558 WP_011060984.1 helix-turn-helix domain-containing protein Antitoxin
D3X12_RS18520 3940059..3940658 + 600 WP_011060985.1 HD domain-containing protein Toxin
D3X12_RS18525 3940872..3943052 + 2181 WP_011060986.1 catalase/peroxidase HPI -
D3X12_RS18530 3943114..3943800 - 687 WP_011060987.1 hypothetical protein -
D3X12_RS18535 3943760..3944380 - 621 WP_011060988.1 hypothetical protein -
D3X12_RS18540 3944428..3944856 - 429 WP_011060989.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(8-193)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-48)


Sequences

Toxin        


Download         Length: 200 a.a.        Molecular weight: 22413.22 Da        Isoelectric Point: 5.8382

>T111704 WP_011060985.1 NZ_CP032358:3940059-3940658 [Pseudomonas protegens]
MNSELLSGRLEFLREAEKLKDVLRSAHTSSGRQESTAEHSWRLCLMALLFEDQLGDLDLLRVLKLCIVHDLGEAIHGDIP
AVAQAAHPDKSPQERADLQLLARALDAPAREHLLELWDEYEGAASNEARAVKALDKLETLLQHTQGQNPAGFDYRFNLGY
GRRYTDASPLFQALRQQIDADTQRRLDAQAQAAVQHRLR

Download         Length: 600 bp

>T111704 NZ_CP032358:3940059-3940658 [Pseudomonas protegens]
ATGAACAGTGAACTTCTCAGTGGCCGCCTTGAATTCCTCCGTGAAGCGGAAAAACTCAAGGACGTGCTGCGCAGTGCCCA
CACCTCCAGCGGCCGCCAGGAAAGCACCGCCGAGCACAGCTGGCGCCTGTGCCTGATGGCGCTGCTGTTCGAAGACCAAC
TGGGGGATCTGGACCTACTGCGGGTGCTGAAGCTGTGCATCGTTCACGACCTGGGGGAGGCCATTCACGGCGATATCCCG
GCGGTGGCCCAGGCCGCCCACCCGGACAAGAGCCCGCAGGAGCGCGCGGACCTGCAACTGCTGGCCCGAGCCCTGGACGC
CCCGGCCCGCGAGCACCTGCTGGAGCTGTGGGACGAATACGAAGGCGCCGCCAGCAACGAGGCGCGCGCGGTCAAGGCCC
TGGACAAGCTGGAAACCCTGCTGCAACACACCCAGGGCCAGAACCCGGCGGGTTTCGACTACCGCTTCAACCTCGGCTAC
GGCCGCCGCTACACCGATGCCAGCCCGCTGTTCCAGGCCCTGCGCCAGCAGATCGATGCCGACACCCAGCGCCGCCTGGA
CGCCCAGGCTCAGGCCGCGGTTCAGCATCGGCTGCGCTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20446.44 Da        Isoelectric Point: 7.4189

>AT111704 WP_011060984.1 NZ_CP032358:3939383-3939940 [Pseudomonas protegens]
MSVALFTSPHLGLALRRWRLLHRVKQQHAAELFGVAQSSISRWENGRQAMEPAERARLEQLLAANLSAAADQALARLVHD
SPRAVHLVCDLTHRLLACSVTRAGQFGVPLSELLGQSLWGFCTEEIVRKEAALDDLGWREVLAPPSLEFFSGHNDSAIVP
IAPSQCRWTRLNLSDGNAVRLVETL

Download         Length: 558 bp

>AT111704 NZ_CP032358:3939383-3939940 [Pseudomonas protegens]
ATGTCCGTAGCTCTGTTCACCTCACCCCATCTGGGCCTGGCCCTCAGGCGCTGGCGCCTGTTGCACCGGGTCAAGCAGCA
GCACGCCGCCGAGTTGTTCGGTGTGGCGCAGTCGAGCATTTCCCGCTGGGAAAACGGCCGGCAAGCCATGGAACCGGCGG
AACGCGCGCGCTTGGAGCAACTGCTGGCGGCCAACCTCAGCGCCGCCGCCGACCAGGCCCTGGCGCGGCTGGTGCATGAC
AGCCCGCGCGCCGTGCACCTGGTGTGCGACCTGACCCACCGCCTGCTGGCCTGTTCCGTGACCCGCGCCGGGCAGTTCGG
CGTGCCCCTGAGCGAGCTGCTGGGGCAATCCCTGTGGGGCTTTTGCACCGAGGAAATCGTGCGCAAGGAAGCCGCCCTGG
ATGACCTGGGCTGGCGCGAAGTACTGGCCCCGCCGTCCCTGGAATTCTTCAGCGGCCACAACGATTCGGCCATCGTGCCC
ATCGCCCCCAGCCAGTGCCGCTGGACCCGCCTCAACCTCTCCGACGGCAACGCCGTGCGGCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4KD87

Antitoxin

Source ID Structure

References