Detailed information of TA system TA111672

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3028949..3029465
• Replicon: chromosome
• Accession: NZ_CP032352
• Organism: Pseudomonas protegens strain pf5-k3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F9XXF1
• Locus tag: D4N38_RS14160
• Protein ID: WP_011058535.1
• Coordinates: 3028949..3029230 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q4KKD3
• Locus tag: D4N38_RS14165
• Protein ID: WP_011058534.1
• Coordinates: 3029220..3029465 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D4N38_RS14140	3025201..3026091	-	891	WP_011058539.1	HlyD family secretion protein	-
D4N38_RS14145	3026088..3026297	-	210	WP_011058538.1	DUF1656 domain-containing protein	-
D4N38_RS14150	3026294..3028381	-	2088	WP_011058537.1	FUSC family protein	-
D4N38_RS14155	3028378..3028806	-	429	WP_011058536.1	winged helix DNA-binding protein	-
D4N38_RS14160	3028949..3029230	-	282	WP_011058535.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D4N38_RS14165	3029220..3029465	-	246	WP_011058534.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D4N38_RS14170	3029530..3029775	-	246	WP_011058533.1	DUF2789 domain-containing protein	-
D4N38_RS14175	3029790..3030251	-	462	WP_011058532.1	YbaK/EbsC family protein	-
D4N38_RS14180	3030361..3031971	-	1611	WP_011058531.1	glycosyltransferase family 39 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-69)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10839.72 Da
• Isoelectric Point: 10.2298

>T111672 WP_011058535.1 NZ_CP032352:c3029230-3028949 [Pseudomonas protegens]
MTYSLEFLPSAHKEWNKLGHTLREQFKKKLAERLEVPRIPADALHGLPDCYKIKLKASGYRLVYQVIEERVVVCVVAVGK
RERGTVYEQARKR

Nucleotide

• Length: 282 bp

>T111672 NZ_CP032352:c3029230-3028949 [Pseudomonas protegens]
ATGACTTATAGCCTTGAGTTCCTGCCTTCGGCACACAAGGAATGGAACAAGTTGGGGCATACGCTTCGAGAGCAATTCAA
GAAAAAGCTCGCCGAACGGCTTGAGGTGCCGCGAATCCCTGCTGATGCCCTGCATGGGCTTCCCGATTGCTACAAAATTA
AACTCAAGGCTTCGGGCTACCGATTGGTTTATCAAGTGATCGAAGAGCGCGTCGTGGTTTGCGTGGTTGCGGTCGGCAAG
CGCGAGCGTGGAACCGTTTACGAGCAGGCCAGGAAACGCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8799.10 Da
• Isoelectric Point: 4.3988

>AT111672 WP_011058534.1 NZ_CP032352:c3029465-3029220 [Pseudomonas protegens]
MQSILADKAVSVSELKKNPSAVLSGAQGGPVAVLNHNRVMGYMVPAEVFEALMERLDDLELAEIIRERSHETPVPVSLDD
L

Nucleotide

• Length: 246 bp

>AT111672 NZ_CP032352:c3029465-3029220 [Pseudomonas protegens]
ATGCAGAGTATTCTGGCTGACAAAGCCGTCAGCGTATCTGAGTTGAAGAAAAACCCTTCTGCCGTCTTGAGTGGTGCCCA
GGGCGGGCCAGTGGCGGTGTTGAATCACAATCGTGTCATGGGCTACATGGTTCCGGCCGAGGTTTTCGAAGCGTTGATGG
AACGCCTGGATGATCTGGAGTTGGCCGAAATCATCCGCGAGCGCAGCCATGAGACGCCCGTTCCGGTCAGTCTGGATGAC
TTATAG

Structures

Toxin

• AlphaFold DB: F9XXF1

Antitoxin

• AlphaFold DB: Q4KKD3