Detailed information of TA system TA111668

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 4255534..4256039
• Replicon: chromosome
• Accession: NZ_CP032329
• Organism: Xenorhabdus nematophila strain YL001

Toxin (Protein)

• Gene name: relB
• Uniprot ID: D3VB03
• Locus tag: D3790_RS19580
• Protein ID: WP_013185277.1
• Coordinates: 4255534..4255788 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D3790_RS19585
• Protein ID: WP_041976483.1
• Coordinates: 4255785..4256039 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D3790_RS19560	4251327..4252325	+	999	WP_013185281.1	ketoacyl-ACP synthase III	-
D3790_RS19565	4252322..4253341	+	1020	WP_013185280.1	NAD(P)-dependent oxidoreductase	-
D3790_RS19570	4253334..4254140	+	807	WP_013185279.1	MBL fold metallo-hydrolase	-
D3790_RS19575	4254137..4255414	+	1278	WP_013185278.1	coenzyme F390 synthetase	-
D3790_RS19580	4255534..4255788	-	255	WP_013185277.1	Txe/YoeB family addiction module toxin	Toxin
D3790_RS19585	4255785..4256039	-	255	WP_041976483.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
D3790_RS19590	4256183..4256953	-	771	WP_010846253.1	Fe(3+) dicitrate ABC transporter ATP-binding protein FecE	-
D3790_RS19595	4256954..4257910	-	957	WP_010846252.1	Fe(3+) dicitrate ABC transporter permease subunit FecD	-
D3790_RS19600	4257907..4258905	-	999	WP_013185273.1	iron-dicitrate ABC transporter permease FecC	-
D3790_RS19605	4258902..4259804	-	903	WP_113935488.1	Fe(3+) dicitrate ABC transporter substrate-binding protein FecB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10245.67 Da
• Isoelectric Point: 8.8345

>T111668 WP_013185277.1 NZ_CP032329:c4255788-4255534 [Xenorhabdus nematophila]
MILSWAETAWEDYLYWQQTDKKTLKRINTLIKDIARQSFDGLGDPEPLKHNWSGYWSRRIDREHRLVYKVTDTAIIIVQC
RYHY

Nucleotide

• Length: 255 bp

>T111668 NZ_CP032329:c4255788-4255534 [Xenorhabdus nematophila]
ATGATTCTATCTTGGGCAGAAACGGCGTGGGAAGATTATCTTTATTGGCAACAAACCGATAAAAAAACCCTAAAACGCAT
TAATACTCTTATTAAGGATATTGCCCGACAGTCTTTTGATGGGCTAGGTGATCCTGAACCCTTAAAACATAACTGGTCAG
GATACTGGTCCAGGCGGATTGATCGTGAGCATCGCCTAGTTTATAAGGTTACAGACACCGCAATAATTATTGTTCAATGT
CGCTATCACTACTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9481.75 Da
• Isoelectric Point: 5.0893

>AT111668 WP_041976483.1 NZ_CP032329:c4256039-4255785 [Xenorhabdus nematophila]
MNVMSYSAFRTHLAKTLDKVNDDHQPVMITRQNGKPAVVLSLEDFRAYEETAYLMASPKNAARLNQAIAEVENGKTLEKD
LLEE

Nucleotide

• Length: 255 bp

>AT111668 NZ_CP032329:c4256039-4255785 [Xenorhabdus nematophila]
ATGAATGTTATGAGCTATTCAGCATTTCGAACTCATTTAGCTAAAACTCTGGATAAAGTGAACGATGACCACCAACCCGT
GATGATCACTCGTCAGAATGGTAAGCCAGCAGTTGTACTCAGTTTGGAGGATTTTCGGGCTTATGAAGAAACTGCCTATT
TGATGGCAAGCCCTAAAAATGCAGCGCGCCTAAACCAAGCTATTGCAGAGGTAGAAAATGGTAAAACTCTTGAAAAAGAC
TTACTGGAAGAATGA

Structures

Toxin

• AlphaFold DB: D3VB03