Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3779137..3780687 Replicon chromosome
Accession NZ_CP032329
Organism Xenorhabdus nematophila strain YL001

Toxin (Protein)


Gene name hipA Uniprot ID N1NQE2
Locus tag D3790_RS17340 Protein ID WP_010847710.1
Coordinates 3779389..3780687 (+) Length 433 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID N1NPE2
Locus tag D3790_RS17335 Protein ID WP_010847709.1
Coordinates 3779137..3779388 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D3790_RS17315 3774434..3775717 + 1284 WP_013185552.1 serine hydroxymethyltransferase -
D3790_RS17320 3775683..3776444 - 762 WP_013183573.1 IS5 family transposase -
D3790_RS17325 3777140..3778180 + 1041 Protein_3306 IS630 family transposase -
D3790_RS17330 3778320..3779033 - 714 Protein_3307 IS630 family transposase -
D3790_RS17335 3779137..3779388 + 252 WP_010847709.1 helix-turn-helix domain-containing protein Antitoxin
D3790_RS17340 3779389..3780687 + 1299 WP_010847710.1 type II toxin-antitoxin system HipA family toxin Toxin
D3790_RS17345 3781080..3782360 + 1281 WP_013185547.1 dicarboxylate/amino acid:cation symporter -
D3790_RS17350 3782515..3783405 - 891 WP_038220625.1 LysR family transcriptional regulator -
D3790_RS17355 3783534..3784226 + 693 WP_041977848.1 amino acid racemase -
D3790_RS17360 3784747..3785667 - 921 WP_041977851.1 DUF91 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3777140..3778006 866


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 48428.67 Da        Isoelectric Point: 7.2017

>T111666 WP_010847710.1 NZ_CP032329:3779389-3780687 [Xenorhabdus nematophila]
MNKLIVALNGLEVGVLFRDKKGAMSFQYTNEWLKEPGTRAISLSLPLSNQKYVGQEVFNFFDNLLPDSREIIARMQARFQ
ITSKHPFDLLASVGRDCVGAIQLYQEGNQIPPIDEVHAEPLDERAIVELLEGYKTTPLGMNNSDNFRISLAGAQEKTALL
WHQGCWQRPYGSTPTSHIFKLPIGRIEHNNIDLHESCENEWLCLKIARTFGLPVANAELAKFGEKTVLIVERFDRRWSCD
NRWLMRLPQEDMCQAMGIAPALKYEADGGPGIADIMTLLLGSRNSITDRETFFKSQILYWLLAAIDGHGKNFSIFIEPDS
SYSMTPLYDILSAYPIFGAKGVAPKKAKMAMALRGKSRQYHWATIQPRHFPSTARQVGFSESMAEKLMNEMGNMAEKVIN
QVANELPPNFPGHISDAIFTGLAKQAGRLCAG

Download         Length: 1299 bp

>T111666 NZ_CP032329:3779389-3780687 [Xenorhabdus nematophila]
ATGAACAAATTGATCGTTGCATTGAATGGGCTGGAAGTGGGGGTCTTGTTTCGTGATAAAAAAGGAGCCATGTCTTTCCA
GTACACAAATGAGTGGCTGAAAGAACCCGGTACTCGTGCAATATCACTTTCTTTACCTCTCAGTAACCAGAAATATGTAG
GTCAGGAAGTATTCAATTTCTTCGATAATTTATTACCCGATTCAAGGGAAATCATAGCCCGTATGCAGGCTAGATTTCAG
ATAACCAGTAAGCATCCATTCGATCTCTTAGCCAGTGTTGGGAGGGACTGTGTTGGCGCTATTCAGCTCTATCAGGAAGG
TAATCAAATTCCTCCAATTGACGAGGTTCACGCTGAGCCTTTGGATGAGCGGGCAATAGTCGAGTTGCTTGAAGGCTACA
AGACGACGCCTTTAGGGATGAACAATAGTGACAATTTCCGGATCTCTTTGGCTGGCGCGCAGGAAAAAACAGCCCTTCTA
TGGCATCAAGGCTGTTGGCAGCGACCTTACGGGAGTACGCCTACGAGTCATATATTTAAACTCCCCATAGGCAGAATTGA
GCACAATAATATCGATCTTCACGAGAGTTGTGAAAATGAATGGTTGTGTTTAAAAATCGCCCGAACATTCGGTCTTCCTG
TTGCAAATGCAGAGTTAGCGAAGTTTGGAGAAAAGACAGTATTGATTGTCGAACGTTTTGATCGCCGTTGGTCTTGTGAT
AATCGGTGGTTGATGCGTCTTCCTCAAGAGGATATGTGTCAGGCTATGGGGATTGCTCCTGCTCTTAAATATGAAGCAGA
TGGAGGTCCTGGGATTGCAGATATCATGACGTTGCTACTCGGCTCCAGAAACTCAATAACAGATCGAGAAACGTTTTTTA
AATCCCAAATTCTATATTGGTTATTGGCTGCGATAGATGGACATGGCAAAAATTTCAGCATTTTTATCGAGCCAGATTCG
TCTTACTCGATGACTCCTCTTTATGATATTTTGTCAGCTTATCCTATCTTTGGTGCTAAGGGAGTTGCTCCAAAGAAAGC
AAAAATGGCGATGGCTTTACGTGGTAAGAGTCGCCAGTATCATTGGGCTACCATTCAACCCAGACATTTTCCAAGTACTG
CTCGTCAGGTTGGTTTTTCTGAATCAATGGCTGAAAAGCTGATGAACGAGATGGGAAATATGGCCGAAAAGGTAATAAAC
CAAGTAGCTAATGAGCTGCCACCTAATTTTCCCGGTCATATCAGCGATGCAATTTTTACTGGTTTGGCTAAACAAGCGGG
CAGGCTTTGTGCAGGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9479.82 Da        Isoelectric Point: 10.9422

>AT111666 WP_010847709.1 NZ_CP032329:3779137-3779388 [Xenorhabdus nematophila]
MKITSPQTLAVAIREQRKKKRLTQKDTADRVGIKQSTVSGFENSPEKSKLETLFKLLSSLGLELQVTERNGSTKSDSRWT
REW

Download         Length: 252 bp

>AT111666 NZ_CP032329:3779137-3779388 [Xenorhabdus nematophila]
ATGAAGATCACATCACCACAAACACTGGCTGTAGCAATCAGGGAACAGCGCAAAAAAAAGCGCCTGACCCAAAAAGACAC
TGCTGATCGGGTTGGAATAAAGCAGAGTACCGTTTCTGGATTTGAAAACAGTCCGGAAAAAAGCAAGCTGGAAACCTTGT
TTAAATTGCTTTCTTCGCTAGGTTTGGAACTGCAAGTTACAGAGCGCAATGGTTCAACAAAGTCAGATAGTCGCTGGACA
AGGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N1NQE2

Antitoxin

Source ID Structure
AlphaFold DB N1NPE2

References