Detailed information of TA system TA111658

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3234534..3236272
• Replicon: chromosome
• Accession: NZ_CP032329
• Organism: Xenorhabdus nematophila strain YL001

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: D3790_RS14605
• Protein ID: WP_041979641.1
• Coordinates: 3235373..3236272 (+)
• Length: 300 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: N1NP62
• Locus tag: D3790_RS14600
• Protein ID: WP_010847657.1
• Coordinates: 3234534..3235310 (+)
• Length: 259 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D3790_RS14570	3229777..3230964	-	1188	WP_038219097.1	multidrug efflux MFS transporter EmrD	-
D3790_RS14575	3231276..3232022	+	747	WP_038219098.1	ferredoxin--NADP(+) reductase	-
D3790_RS14580	3232037..3232483	-	447	WP_038219114.1	DUF805 domain-containing protein	-
D3790_RS14585	3232542..3233162	+	621	WP_038219100.1	DUF1454 family protein	-
D3790_RS14590	3233251..3234018	+	768	WP_038219101.1	triose-phosphate isomerase	-
D3790_RS14600	3234534..3235310	+	777	WP_010847657.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
D3790_RS14605	3235373..3236272	+	900	WP_041979641.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
D3790_RS14610	3236514..3236912	-	399	WP_013183155.1	type II toxin-antitoxin system death-on-curing family toxin	-
D3790_RS14615	3236909..3237130	-	222	WP_010847654.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
D3790_RS14620	3237389..3237949	-	561	Protein_2787	DUF4102 domain-containing protein	-
D3790_RS14630	3238277..3239101	-	825	WP_038219103.1	DNA damage-inducible protein D	-
D3790_RS14640	3239811..3240023	-	213	WP_113935543.1	ogr/Delta-like zinc finger family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (6-250)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (100-250)

Sequences

Toxin

Protein

• Length: 300 a.a.
• Molecular weight: 34215.47 Da
• Isoelectric Point: 5.0397

>T111658 WP_041979641.1 NZ_CP032329:3235373-3236272 [Xenorhabdus nematophila]
MLPVVAQEKMFALKGGTAINLFVREFPRLSVDIDLAYLPLEPRDVALVNVRAALQRIVDNINVQPNVTAILQDNKTDELR
IVISNNNATIKIEISPVARGTLHKPEDRAVVEFVEDEFGYAEISVVSLPDLYGGKICAAMDRQHPRDLFDVKMLLNEEGI
SRDIFIGFLTYALSHKRPINEIMAPNWQSMGEKFSREFEGMTLEQVELAELEAIRFEMLAELQKHLTEKDRHFLLSFKRG
EPDWALFDALSAADLPAIRWKLLNIETLKTKNPDKHQEQLKKLEQVLDQWLKKAELNSQ

Nucleotide

• Length: 900 bp

>T111658 NZ_CP032329:3235373-3236272 [Xenorhabdus nematophila]
ATGTTGCCTGTTGTAGCTCAAGAGAAAATGTTTGCACTAAAAGGTGGGACAGCTATCAACCTGTTTGTACGTGAATTCCC
TCGTCTGTCTGTGGATATCGACTTGGCATATTTACCATTAGAACCAAGAGATGTAGCGTTGGTGAATGTCCGTGCTGCGC
TACAACGCATTGTCGACAATATTAATGTTCAACCCAATGTCACAGCGATTTTACAAGATAACAAAACCGATGAACTTCGT
ATTGTTATTTCCAATAACAATGCCACCATTAAAATAGAAATTTCTCCGGTTGCACGAGGTACCTTACACAAACCAGAAGA
TAGAGCGGTTGTTGAATTTGTGGAGGATGAATTTGGCTATGCTGAAATTTCAGTAGTCAGTTTGCCTGATCTTTATGGTG
GAAAAATTTGCGCTGCGATGGACAGGCAACATCCGAGGGATCTGTTCGATGTGAAGATGCTCTTAAACGAAGAAGGTATT
TCACGAGATATCTTTATAGGTTTTTTAACTTACGCACTGAGTCATAAAAGGCCAATTAACGAAATAATGGCCCCAAACTG
GCAATCAATGGGCGAGAAATTCTCTCGCGAGTTCGAGGGAATGACACTTGAACAGGTTGAGCTGGCAGAACTGGAAGCAA
TCCGCTTCGAAATGCTTGCTGAGTTACAAAAACATCTAACTGAAAAAGACCGTCACTTTTTGCTGTCGTTTAAACGAGGA
GAACCTGATTGGGCACTGTTTGATGCACTTTCTGCTGCCGATTTACCCGCTATTCGTTGGAAGTTACTCAACATTGAAAC
GCTAAAAACAAAAAATCCGGATAAGCATCAAGAGCAACTGAAAAAACTTGAGCAAGTGTTAGATCAATGGTTAAAAAAAG
CCGAACTTAATTCTCAATAA

Antitoxin

Protein

• Length: 259 a.a.
• Molecular weight: 29804.00 Da
• Isoelectric Point: 9.9742

>AT111658 WP_010847657.1 NZ_CP032329:3234534-3235310 [Xenorhabdus nematophila]
MNSKINWLVNHTTPGSLVLQQWLVENGISHSLTQKYAQNGWLKKLFTGVYYRPDPIKNHIPNWADALQALADQIHLQIHI
SGLTSLTHQGLSHYLPLKSEKVWIGVRNKQSLPKWFKEFPNQNWQYCNNSKLRELSDKDFTIVLVNGKELKASTPELAAY
EAVDSIGKHISFEHTAELFQGLVNLSPRKVQSLLNRSKAVQTNRIFLYLSHYHDHQWVKRLDESQIELGSGKRQVVTQGR
YDERYKITIPESLIPKSQ

Nucleotide

• Length: 777 bp

>AT111658 NZ_CP032329:3234534-3235310 [Xenorhabdus nematophila]
ATGAACTCAAAAATAAACTGGTTAGTAAATCATACAACGCCTGGCTCACTGGTTCTGCAACAGTGGCTGGTTGAAAATGG
TATCAGCCACTCCCTGACTCAAAAGTACGCTCAGAATGGTTGGTTAAAAAAGCTGTTCACTGGTGTCTACTATCGTCCCG
ATCCAATAAAAAATCATATACCGAATTGGGCTGATGCACTGCAAGCTTTAGCTGATCAAATTCATTTACAGATTCATATT
TCCGGTTTAACTAGTTTGACTCATCAAGGACTTAGCCATTATTTGCCTCTGAAATCAGAAAAGGTATGGATAGGAGTGAG
AAATAAACAATCTCTTCCTAAGTGGTTTAAAGAGTTTCCCAACCAAAACTGGCAGTATTGCAACAACAGTAAACTGAGAG
AATTGTCAGACAAAGATTTCACAATCGTTCTGGTCAATGGAAAAGAACTCAAAGCGAGTACACCGGAACTGGCAGCTTAT
GAAGCCGTCGATTCAATTGGCAAACACATTAGCTTTGAGCACACTGCTGAGCTGTTTCAGGGACTGGTCAATTTGAGCCC
CCGAAAAGTGCAGTCATTACTCAATCGCAGCAAAGCTGTTCAAACCAACCGCATTTTCCTTTATCTAAGCCACTATCACG
ATCACCAGTGGGTAAAACGCCTTGATGAGTCACAGATTGAACTAGGCTCAGGTAAGCGCCAAGTTGTGACCCAAGGACGG
TATGACGAACGCTATAAAATCACGATTCCTGAATCTTTAATTCCTAAAAGCCAATGA

Structures

Antitoxin

• AlphaFold DB: N1NP62