Detailed information of TA system TA111653

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1993060..1993477
• Replicon: chromosome
• Accession: NZ_CP032329
• Organism: Xenorhabdus nematophila strain YL001

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D3790_RS08575
• Protein ID: WP_010847386.1
• Coordinates: 1993060..1993233 (-)
• Length: 58 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: N1NP74
• Locus tag: D3790_RS08580
• Protein ID: WP_010847387.1
• Coordinates: 1993223..1993477 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D3790_RS08555	1988401..1988985	+	585	WP_143767639.1	manganese efflux pump MntP	-
D3790_RS08560	1989095..1989916	-	822	WP_010847383.1	23S rRNA (guanine(745)-N(1))-methyltransferase	-
D3790_RS08565	1990200..1991528	-	1329	WP_010847384.1	MFS transporter	-
D3790_RS08570	1991537..1993060	-	1524	WP_038220282.1	signal transduction histidine-protein kinase/phosphatase UhpB	-
D3790_RS08575	1993060..1993233	-	174	WP_010847386.1	hypothetical protein	Toxin
D3790_RS08580	1993223..1993477	-	255	WP_010847387.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
D3790_RS08585	1993917..1994297	+	381	WP_119365265.1	transposase	-
D3790_RS08590	1994304..1994921	-	618	WP_010847389.1	transcriptional regulator UhpA	-
D3790_RS08595	1995063..1996439	-	1377	WP_010847390.1	hexose-6-phosphate:phosphate antiporter	-
D3790_RS08600	1997055..1997390	-	336	WP_038220280.1	hypothetical protein	-
D3790_RS08605	1997776..1998465	+	690	WP_038220279.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-74)

Sequences

Toxin

Protein

• Length: 58 a.a.
• Molecular weight: 6931.05 Da
• Isoelectric Point: 10.1541

>T111653 WP_010847386.1 NZ_CP032329:c1993233-1993060 [Xenorhabdus nematophila]
MIFNIEFDERAGKEWQKLDNSIREQFKKKLKKLQKNPYIEPARLHGDLACFLRNFSF

Nucleotide

• Length: 174 bp

>T111653 NZ_CP032329:c1993233-1993060 [Xenorhabdus nematophila]
ATGATATTTAATATCGAGTTTGACGAACGCGCTGGAAAAGAATGGCAAAAGCTGGATAACAGCATTCGTGAACAGTTTAA
AAAGAAGCTGAAAAAGTTACAGAAAAACCCTTATATCGAGCCTGCCAGACTACATGGCGATTTAGCGTGTTTTCTGAGGA
ATTTTTCTTTTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9831.21 Da
• Isoelectric Point: 4.7025

>AT111653 WP_010847387.1 NZ_CP032329:c1993477-1993223 [Xenorhabdus nematophila]
MSTIQIRVDEELKKSAYQAFDKLNLSPSDAMRLFLRYVAEHEKLPFTEVSVMVAEHDEDEDILDVVRDRLKNPAKRIRVN
LDDI

Nucleotide

• Length: 255 bp

>AT111653 NZ_CP032329:c1993477-1993223 [Xenorhabdus nematophila]
ATGAGCACCATCCAAATAAGAGTAGATGAAGAGCTTAAGAAAAGTGCATATCAGGCATTTGATAAGCTGAATCTGTCCCC
TTCTGATGCAATGCGACTCTTCCTGCGTTATGTGGCAGAACATGAAAAGCTACCATTTACTGAGGTATCGGTGATGGTTG
CAGAGCACGATGAAGATGAAGATATTCTGGATGTAGTACGCGATCGCCTAAAGAATCCTGCCAAACGAATCCGGGTAAAT
CTCGATGATATTTAA

Structures

Antitoxin

• AlphaFold DB: N1NP74