Detailed information of TA system TA111652

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 1620190..1620941
• Replicon: chromosome
• Accession: NZ_CP032329
• Organism: Xenorhabdus nematophila strain YL001

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: N1NQL5
• Locus tag: D3790_RS07120
• Protein ID: WP_010845782.1
• Coordinates: 1620190..1620678 (-)
• Length: 163 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: N1NPQ2
• Locus tag: D3790_RS07125
• Protein ID: WP_010845781.1
• Coordinates: 1620669..1620941 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D3790_RS07105	1615192..1616580	-	1389	WP_038218974.1	Re/Si-specific NAD(P)(+) transhydrogenase subunit beta	-
D3790_RS07110	1616591..1618123	-	1533	WP_010845786.1	Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha	-
D3790_RS07115	1619090..1620043	+	954	WP_038218973.1	DUF1471 domain-containing protein	-
D3790_RS07120	1620190..1620678	-	489	WP_010845782.1	GNAT family N-acetyltransferase	Toxin
D3790_RS07125	1620669..1620941	-	273	WP_010845781.1	DUF1778 domain-containing protein	Antitoxin
D3790_RS07130	1621439..1622833	+	1395	WP_038218972.1	basic amino acid/polyamine antiporter	-
D3790_RS07135	1623006..1623767	+	762	WP_038218971.1	IS5 family transposase	-
D3790_RS07140	1624141..1625163	-	1023	WP_119365257.1	IS110 family transposase	-
D3790_RS07145	1625264..1625431	-	168	Protein_1363	IS630 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1625240..1625431	191

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (44-145)

Antitoxin

• Vibrio phage ICP1, Orf50 (5-89)

Sequences

Toxin

Protein

• Length: 163 a.a.
• Molecular weight: 18028.89 Da
• Isoelectric Point: 9.0545

>T111652 WP_010845782.1 NZ_CP032329:c1620678-1620190 [Xenorhabdus nematophila]
VGISTPEILTVKHNVKDFYCQHETLNEWLSRRALKNNKLGASRTFVICKEGTKDVIGYYCLSAGSINHIESTPSLKRNMP
DAIPVMLLGRLAVDAEYQGKKLGALLLQDAWKRVASTAEQVGISAIIVHAFDESARTFYMRLGFVQSPLESYTLMLPLGK
QN

Nucleotide

• Length: 489 bp

>T111652 NZ_CP032329:c1620678-1620190 [Xenorhabdus nematophila]
GTGGGAATAAGTACGCCGGAAATCTTAACGGTTAAACATAATGTAAAGGATTTTTATTGCCAGCATGAAACATTAAACGA
ATGGCTTTCACGCCGGGCTTTAAAAAATAATAAGCTCGGCGCGAGCCGCACATTTGTTATTTGCAAGGAAGGAACAAAAG
ACGTTATCGGTTATTATTGTCTAAGTGCTGGTTCAATTAATCATATTGAATCTACACCATCCCTTAAACGCAATATGCCA
GATGCTATCCCTGTAATGTTGCTCGGCCGCCTAGCTGTTGATGCGGAATATCAGGGGAAGAAGCTCGGTGCATTACTTCT
TCAAGATGCTTGGAAGCGTGTTGCCAGTACGGCGGAACAGGTAGGCATTTCAGCGATAATTGTCCACGCATTTGATGAAA
GCGCCCGAACGTTCTATATGCGTCTAGGTTTCGTCCAGTCACCATTGGAGTCATATACACTGATGCTTCCATTAGGCAAA
CAGAACTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10497.99 Da
• Isoelectric Point: 7.2775

>AT111652 WP_010845781.1 NZ_CP032329:c1620941-1620669 [Xenorhabdus nematophila]
MRTQPKETPINIRAKAFQRELIDHAANLHSKTRTDFILDAACRAAEEAILDQRHFFVNDEKYQAFMQMLEQPLSDNAGFK
KLMGYKAPWE

Nucleotide

• Length: 273 bp

>AT111652 NZ_CP032329:c1620941-1620669 [Xenorhabdus nematophila]
ATGAGAACACAACCTAAAGAAACCCCGATTAACATCCGGGCGAAAGCCTTCCAGCGGGAACTTATCGACCATGCAGCAAA
CCTACATTCGAAGACACGAACTGATTTCATCTTGGATGCTGCCTGCCGAGCTGCTGAAGAGGCCATACTCGATCAGCGCC
ACTTTTTTGTTAACGACGAAAAATATCAGGCGTTCATGCAGATGCTGGAACAACCGCTTTCTGATAACGCAGGTTTTAAA
AAGCTCATGGGATATAAAGCACCGTGGGAATAA

Structures

Toxin

• AlphaFold DB: N1NQL5

Antitoxin

• AlphaFold DB: N1NPQ2