Detailed information of TA system TA111651

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 502445..502970
• Replicon: chromosome
• Accession: NZ_CP032329
• Organism: Xenorhabdus nematophila strain YL001

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D3790_RS02500
• Protein ID: WP_038220597.1
• Coordinates: 502445..502729 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: N1NTS9
• Locus tag: D3790_RS02505
• Protein ID: WP_010848882.1
• Coordinates: 502719..502970 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D3790_RS02480	497903..498811	-	909	WP_041979535.1	oxygen-dependent coproporphyrinogen oxidase	-
D3790_RS02485	499075..500031	-	957	WP_119365228.1	IS110 family transposase	-
D3790_RS02490	500481..501017	+	537	WP_013184731.1	gluconokinase	-
D3790_RS02495	501017..502354	+	1338	WP_010848884.1	gluconate transporter	-
D3790_RS02500	502445..502729	-	285	WP_038220597.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D3790_RS02505	502719..502970	-	252	WP_010848882.1	plasmid stabilization protein	Antitoxin
D3790_RS02510	503051..503789	-	739	Protein_486	SGNH/GDSL hydrolase family protein	-
D3790_RS02515	503747..504733	-	987	WP_041977763.1	DUF459 domain-containing protein	-
D3790_RS02520	504720..505562	-	843	Protein_488	MBOAT family protein	-
D3790_RS02525	505660..506559	+	900	WP_038219493.1	IS982 family transposase	-
D3790_RS02530	506575..506920	-	346	Protein_490	MBOAT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	302732..561677	258945

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10944.67 Da
• Isoelectric Point: 10.2279

>T111651 WP_038220597.1 NZ_CP032329:c502729-502445 [Xenorhabdus nematophila]
MTYSLKFEKRALKEWEKLGHPIREQFKKKLPERLENPHISSARLSGRNNLYKIKLCSSGYRLVYEVNDHAIVLLVIAVGK
RSGNQVYSVADERE

Nucleotide

• Length: 285 bp

>T111651 NZ_CP032329:c502729-502445 [Xenorhabdus nematophila]
ATGACTTATAGTCTCAAATTTGAAAAGCGGGCACTAAAAGAGTGGGAAAAACTAGGGCATCCTATCCGTGAGCAGTTCAA
AAAGAAATTGCCTGAGCGTTTAGAAAACCCCCATATATCTTCAGCTCGATTGAGTGGCCGCAATAATCTCTACAAAATCA
AATTATGTTCTTCTGGCTATCGTTTAGTCTACGAAGTCAATGATCATGCTATTGTTTTACTGGTGATCGCTGTTGGTAAA
AGATCTGGAAATCAGGTTTATTCAGTCGCTGATGAACGTGAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9140.29 Da
• Isoelectric Point: 3.9282

>AT111651 WP_010848882.1 NZ_CP032329:c502970-502719 [Xenorhabdus nematophila]
MSYQILTTIAASITDLKRNPMGTVADGEGGAVAILNRNEPAFYCVPPELYAYYLELAEDAELNHIADERMKSAEFVSVDL
NDL

Nucleotide

• Length: 252 bp

>AT111651 NZ_CP032329:c502970-502719 [Xenorhabdus nematophila]
ATGTCTTATCAGATCCTGACAACAATAGCAGCCAGCATTACCGATTTGAAACGCAATCCCATGGGAACCGTCGCTGATGG
TGAAGGTGGTGCTGTCGCTATCCTGAACCGTAATGAACCTGCATTCTATTGTGTTCCACCGGAGCTTTACGCTTACTATT
TAGAGCTTGCAGAGGATGCAGAATTAAATCACATCGCAGATGAACGGATGAAATCCGCTGAATTTGTGAGCGTCGATCTC
AATGACTTATAG

Structures

Antitoxin

• AlphaFold DB: N1NTS9