Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 4379301..4380991 Replicon chromosome
Accession NZ_CP032311
Organism Pseudomonas sp. DG56-2

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag D3Z90_RS20060 Protein ID WP_136477670.1
Coordinates 4379301..4380170 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag D3Z90_RS20065 Protein ID WP_136477671.1
Coordinates 4380167..4380991 (+) Length 275 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D3Z90_RS20035 4375283..4376134 + 852 WP_136477666.1 ABC transporter ATP-binding protein -
D3Z90_RS20040 4376174..4377172 + 999 WP_136477667.1 ABC transporter substrate-binding protein -
D3Z90_RS20045 4377202..4377978 + 777 WP_136477668.1 ABC transporter permease -
D3Z90_RS20050 4377978..4378742 + 765 WP_136479006.1 SDR family oxidoreductase -
D3Z90_RS20055 4378757..4379296 + 540 WP_136477669.1 cupin domain-containing protein -
D3Z90_RS20060 4379301..4380170 + 870 WP_136477670.1 alpha/beta fold hydrolase Toxin
D3Z90_RS20065 4380167..4380991 + 825 WP_136477671.1 IclR family transcriptional regulator Antitoxin
D3Z90_RS20070 4380993..4381793 + 801 WP_136477672.1 SDR family oxidoreductase -
D3Z90_RS20075 4381786..4383468 + 1683 WP_136477673.1 thiamine pyrophosphate-binding protein -
D3Z90_RS20080 4383479..4384282 + 804 WP_136477674.1 aspartate dehydrogenase -
D3Z90_RS20085 4384293..4385783 + 1491 WP_136477675.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-167)

Antitoxin

Transcription regulator IclR, N-terminal

(19-68)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30571.93 Da        Isoelectric Point: 6.7554

>T111637 WP_136477670.1 NZ_CP032311:4379301-4380170 [Pseudomonas sp. DG56-2]
MLHATDNPTLALPAQLEQRFPLRLVQLDERTQAIREAGQGPAIVLLHGIGSGAASWLQVAVQLSGKARVIAWDAPGYGQS
SPLPDPAPKATDYARRLRQLLDAMDIERCVLVGHSLGALTAAAFACNAPERVSRLVLLSPAQGYGDPARAAQADEVRSKR
LQGLEQLGIAKLAEQRSAHMLSAAANSDARAWVQWNMARLLPQGYRQAIELLCGDHLLRYANHSVPCEVHCGAADSITTA
TDCKALADTLGAAFHLIAAAGHASPIEQPEAVATLLAQALDVSLTGTAL

Download         Length: 870 bp

>T111637 NZ_CP032311:4379301-4380170 [Pseudomonas sp. DG56-2]
ATGTTGCACGCCACCGACAATCCGACCCTCGCGTTGCCCGCCCAGCTGGAGCAACGCTTCCCGCTGCGCCTGGTGCAACT
GGACGAGCGCACGCAAGCGATACGTGAAGCAGGACAGGGTCCGGCCATCGTTCTTTTGCATGGCATCGGTTCAGGGGCCG
CGTCCTGGCTGCAGGTGGCCGTGCAATTGAGTGGCAAAGCACGGGTGATCGCCTGGGATGCACCCGGTTATGGGCAATCC
AGCCCATTGCCTGACCCGGCACCCAAGGCAACGGACTATGCTCGGCGCCTGCGCCAGTTGCTCGATGCGATGGACATTGA
ACGCTGTGTGCTGGTCGGTCACTCCCTCGGCGCCCTCACCGCTGCAGCGTTTGCCTGCAATGCCCCCGAACGAGTCAGCC
GCCTGGTGCTGCTCAGCCCGGCGCAGGGCTACGGCGACCCCGCCCGCGCAGCACAGGCCGATGAAGTGCGCAGCAAGCGC
TTGCAGGGGTTGGAGCAACTGGGCATCGCCAAGCTCGCCGAGCAACGCAGCGCACACATGCTTTCGGCAGCGGCCAACAG
CGATGCGCGCGCCTGGGTGCAATGGAATATGGCGCGTCTGCTGCCACAAGGCTATCGCCAGGCCATCGAACTGTTGTGCG
GCGACCACCTGCTGCGCTACGCGAACCACTCTGTGCCTTGCGAAGTGCACTGCGGGGCCGCCGACAGCATCACCACCGCA
ACCGACTGTAAAGCCCTGGCCGACACCCTGGGCGCTGCGTTTCATCTGATCGCCGCGGCCGGCCACGCCAGCCCGATCGA
ACAACCCGAGGCCGTGGCAACCCTGCTTGCCCAGGCACTCGACGTCTCACTGACAGGTACTGCGCTATGA

Antitoxin


Download         Length: 275 a.a.        Molecular weight: 30252.65 Da        Isoelectric Point: 6.4971

>AT111637 WP_136477671.1 NZ_CP032311:4380167-4380991 [Pseudomonas sp. DG56-2]
MNDSDLLKDNQDKYIVPGLERGLLLLCEFSRQNRTLTAPELARRLELPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDHLNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVNVGTRLPAHATVLGRILLEDLSLA
ELRDLYPEEHLEQHSPCTPKTVLELFDLVQSDRQRGFVSGEGFFESSISTIAAPVRDHSGKVVAAMGVTIPTAQVGHINF
DGLLGHVRGSADELSRLLNYTPHAGGRVTALMRD

Download         Length: 825 bp

>AT111637 NZ_CP032311:4380167-4380991 [Pseudomonas sp. DG56-2]
ATGAATGATTCGGATCTGTTGAAAGACAACCAGGATAAATACATCGTCCCCGGCCTTGAGCGCGGCCTGTTGCTGCTCTG
CGAGTTCAGCCGGCAAAACCGTACCCTGACGGCACCGGAGCTGGCGCGCCGCCTGGAACTGCCGCGTTCGACCATCTTCC
GTCTGCTGACCACCTTGGAAACCATGGGTTTCGTGACCCGTAGTGGCAACGAATATCGCCTGGGCATGTCGGTACTGCGC
CTGGGCTTCGAATACCTCGCCTCGCTGGAACTGACCGAGTTGGGTCAGCCGCTGCTGGCACGCCTGTGCGACCACCTTAA
CTATCCAAGCAACCTGGTGGTGCGTGACGGTCGCTCGATTGTCTATGTGGCCAAGGTCTCGCCGCCGTCGGTGTTCTCCA
GCGCGGTCAACGTCGGTACTCGCCTGCCCGCCCACGCCACGGTGCTCGGCCGCATCCTGCTGGAAGACTTGAGCCTGGCC
GAACTGCGCGATCTGTACCCGGAAGAACACCTCGAGCAGCACTCGCCGTGCACGCCGAAAACCGTGCTGGAGCTGTTCGA
CCTGGTACAGAGCGACCGTCAGCGCGGCTTTGTCAGCGGTGAAGGTTTCTTCGAGTCGTCGATCTCGACCATCGCTGCGC
CGGTGCGTGATCACAGCGGCAAAGTCGTTGCCGCCATGGGGGTAACCATCCCTACCGCGCAAGTTGGCCACATCAACTTC
GATGGCCTGCTTGGCCACGTGCGCGGCAGCGCCGATGAGCTCTCACGCCTGCTCAACTACACGCCCCATGCCGGTGGCCG
TGTTACCGCACTGATGAGGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References