Detailed information of TA system TA111598

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 1528497..1529413
• Replicon: chromosome
• Accession: NZ_CP032296
• Organism: Rahnella aquatilis strain ZF7

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: D3Z09_RS07150
• Protein ID: WP_112151163.1
• Coordinates: 1528497..1528955 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: H2IQN3
• Locus tag: D3Z09_RS07155
• Protein ID: WP_013574723.1
• Coordinates: 1528952..1529413 (-)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D3Z09_RS07125	1524123..1525808	+	1686	WP_013574717.1	choline dehydrogenase	-
D3Z09_RS07130	1525899..1526357	+	459	WP_119261418.1	GNAT family N-acetyltransferase	-
D3Z09_RS07135	1526545..1527477	-	933	WP_119261419.1	LysR family transcriptional regulator	-
D3Z09_RS07140	1527579..1528013	+	435	WP_013574720.1	DMT family transporter	-
D3Z09_RS07145	1528017..1528469	+	453	WP_013574721.1	DMT family transporter	-
D3Z09_RS07150	1528497..1528955	-	459	WP_112151163.1	RES family NAD+ phosphorylase	Toxin
D3Z09_RS07155	1528952..1529413	-	462	WP_013574723.1	DUF2384 domain-containing protein	Antitoxin
D3Z09_RS07160	1529764..1530651	+	888	WP_013574724.1	nucleoside-specific channel-forming protein Tsx	-
D3Z09_RS07165	1530838..1532430	+	1593	WP_015696564.1	ABC-F family ATPase	-
D3Z09_RS07170	1532614..1533375	-	762	WP_013574726.1	molybdopterin-synthase adenylyltransferase MoeB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-135)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (34-95)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17004.58 Da
• Isoelectric Point: 4.7091

>T111598 WP_112151163.1 NZ_CP032296:c1528955-1528497 [Rahnella aquatilis]
MKLFRIVQTRHLATAWSGAGAQLYGGRWNPPGRPVVYVTTSISLAILEILVHLQNSMLMRSYTLLSIEVPEELLDTLEVS
ELAADWRSASVPDSTQRQGDVWLAEGEYVGLKVPSVIVPSEYNVLLNPLHPAFTDLLSSVEREPMMFDPRLQ

Nucleotide

• Length: 459 bp

>T111598 NZ_CP032296:c1528955-1528497 [Rahnella aquatilis]
TTGAAGCTGTTTCGTATCGTGCAGACCCGCCATCTGGCGACAGCCTGGTCGGGAGCTGGCGCGCAACTTTATGGCGGTCG
CTGGAATCCGCCAGGCAGGCCGGTCGTCTATGTCACCACCAGCATCTCACTGGCTATCCTGGAAATTCTGGTGCATTTGC
AAAACAGCATGTTGATGCGTTCCTATACCTTGCTGAGTATTGAGGTGCCAGAGGAACTGCTGGATACGCTGGAAGTTTCA
GAGCTTGCCGCCGACTGGCGAAGCGCATCAGTGCCTGACAGCACTCAACGTCAGGGTGACGTCTGGCTTGCAGAAGGTGA
ATATGTCGGGCTGAAAGTGCCGTCAGTGATTGTGCCGTCGGAATACAACGTATTACTTAATCCGCTACACCCGGCTTTTA
CCGATTTACTGAGTTCAGTAGAACGCGAGCCCATGATGTTTGACCCGCGCCTGCAATAA

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 16505.80 Da
• Isoelectric Point: 7.0196

>AT111598 WP_013574723.1 NZ_CP032296:c1529413-1528952 [Rahnella aquatilis]
MNSKITGLSSSSVQDSATPLWQSAGLPASSGISLINAIQKGFPVDSISRLNTELGWPKMVLLEIMGINERNYARRKAGNG
LLKSEESERVARLVRIVDAATDLFEGDRVSALEWFTRPAPALDGSRPLELLSSEAGAVEVSRLIGRLQHGVFS

Nucleotide

• Length: 462 bp

>AT111598 NZ_CP032296:c1529413-1528952 [Rahnella aquatilis]
ATGAATTCAAAAATTACCGGGCTGTCTTCCAGCTCTGTGCAAGATTCTGCAACGCCGCTTTGGCAATCTGCGGGCCTTCC
CGCAAGCAGCGGAATCAGTTTGATAAATGCCATACAAAAGGGATTTCCGGTTGATAGTATCAGCCGTCTTAATACTGAGC
TGGGATGGCCAAAAATGGTGTTACTGGAAATCATGGGCATTAACGAACGCAACTATGCCCGGCGTAAAGCCGGGAACGGA
TTGCTAAAAAGTGAAGAGAGTGAACGTGTGGCGCGACTGGTTCGCATCGTGGATGCCGCAACTGATTTGTTCGAAGGGGA
TCGTGTCTCGGCGCTCGAATGGTTCACCCGCCCTGCTCCGGCACTGGATGGTTCACGTCCGCTGGAACTGCTGTCTTCTG
AAGCGGGTGCTGTGGAAGTCAGCCGCCTGATTGGTCGTCTCCAGCACGGTGTTTTCAGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3F7Y1