Detailed information of TA system TA111593

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 989747..990239
• Replicon: chromosome
• Accession: NZ_CP032295
• Organism: Morganella morganii strain DG56-16

Toxin (Protein)

• Gene name: relE
• Uniprot ID: J7TMG3
• Locus tag: D3Y66_RS04490
• Protein ID: WP_004237651.1
• Coordinates: 990012..990239 (+)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8I0PUC0
• Locus tag: D3Y66_RS04485
• Protein ID: WP_036416691.1
• Coordinates: 989747..990028 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D3Y66_RS04480	984913..989547	+	4635	WP_119312535.1	hemagglutinin repeat-containing protein	-
D3Y66_RS04485	989747..990028	+	282	WP_036416691.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
D3Y66_RS04490	990012..990239	+	228	WP_004237651.1	type II toxin-antitoxin system YafQ family toxin	Toxin
D3Y66_RS04495	990542..992026	+	1485	WP_004237652.1	C69 family dipeptidase	-
D3Y66_RS04500	992117..992569	-	453	WP_004237653.1	NfeD family protein	-
D3Y66_RS04505	992566..993504	-	939	WP_004237654.1	SPFH/Band 7/PHB domain protein	-
D3Y66_RS04510	993560..994417	-	858	WP_015422944.1	co-chaperone YbbN	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-74)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-81)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 9069.63 Da
• Isoelectric Point: 9.9416

>T111593 WP_004237651.1 NZ_CP032295:990012-990239 [Morganella morganii]
MARTIERSSQFKKDYKREVKGIYRMMLNDSLQNILNILVNDLPIPEKYADHPLKGNWRTFRDCHLYPDLILIYKK

Nucleotide

• Length: 228 bp

>T111593 NZ_CP032295:990012-990239 [Morganella morganii]
ATGGCAAGGACGATTGAACGTTCATCTCAGTTTAAAAAAGATTATAAACGGGAAGTTAAGGGTATTTACCGTATGATGTT
AAATGACAGTCTACAGAACATCCTGAATATATTGGTAAATGATCTCCCTATACCTGAAAAATACGCTGATCATCCGCTTA
AAGGAAATTGGCGTACATTTCGTGATTGCCACCTCTATCCTGATTTGATTTTGATTTATAAAAAATAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10438.14 Da
• Isoelectric Point: 5.8765

>AT111593 WP_036416691.1 NZ_CP032295:989747-990028 [Morganella morganii]
MSKVEYVRAKIDPKLKAEAIETLESMGLTVSDAIRMLMIQIVEQKAMPFCVKSTQYRHAARTRAAIEELECGKGKKFDSI
SDLMADLQDGKDD

Nucleotide

• Length: 282 bp

>AT111593 NZ_CP032295:989747-990028 [Morganella morganii]
ATGTCTAAAGTGGAATATGTCAGAGCAAAAATTGATCCGAAGCTGAAAGCAGAAGCGATTGAAACGCTTGAATCGATGGG
CTTAACAGTGAGTGACGCGATAAGAATGTTGATGATTCAGATTGTTGAACAGAAAGCGATGCCATTTTGTGTGAAAAGTA
CACAATATCGTCATGCTGCACGTACCCGGGCCGCAATAGAAGAGTTGGAGTGCGGGAAAGGCAAAAAATTTGACAGTATT
TCAGATTTAATGGCGGATCTGCAGGATGGCAAGGACGATTGA

Structures

Toxin

• AlphaFold DB: J7TMG3