Detailed information of TA system TA111591

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 626806..627359
• Replicon: chromosome
• Accession: NZ_CP032295
• Organism: Morganella morganii strain DG56-16

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: D3Y66_RS02920
• Protein ID: WP_119312472.1
• Coordinates: 627045..627359 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: D3Y66_RS02915
• Protein ID: WP_062814467.1
• Coordinates: 626806..627042 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D3Y66_RS02905	622727..625093	+	2367	WP_062814465.1	TonB-dependent receptor	-
D3Y66_RS02910	625540..626484	+	945	WP_062814466.1	DUF1738 domain-containing protein	-
D3Y66_RS02915	626806..627042	+	237	WP_062814467.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
D3Y66_RS02920	627045..627359	+	315	WP_119312472.1	CcdB family protein	Toxin
D3Y66_RS02925	627356..628108	-	753	WP_119312473.1	molybdopterin-guanine dinucleotide biosynthesis protein MobC	-
D3Y66_RS02930	628117..629853	-	1737	WP_119312474.1	type IV secretion system DNA-binding domain-containing protein	-
D3Y66_RS02945	630633..630938	-	306	WP_062814470.1	hypothetical protein	-
D3Y66_RS02950	630972..631277	-	306	WP_062814471.1	conjugal transfer protein	-
D3Y66_RS02955	631313..631711	-	399	WP_119312475.1	cag pathogenicity island Cag12 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	616276..671908	55632

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11589.57 Da
• Isoelectric Point: 8.8837

>T111591 WP_119312472.1 NZ_CP032295:627045-627359 [Morganella morganii]
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPASRRPDRLVPVVRLTDGKEYAVMTHELASVPVRVLG
TVFCDASQYRTQVKAAIDFLIDGI

Nucleotide

• Length: 315 bp

>T111591 NZ_CP032295:627045-627359 [Morganella morganii]
ATGCAGTTCACCGTATACGGGAATACCGGTAAAAGCGTCGTTTACCCTCTGCTACTCGATGTCACGAGTGATATTATCGG
GCAACTGAACCGCCGGATCGTGATCCCGTTGCTGCCTGTTGAAAAATATCCGGCCAGCCGCCGCCCGGATCGACTTGTCC
CTGTGGTCAGATTAACTGACGGCAAGGAATACGCGGTAATGACCCATGAGCTTGCGAGTGTCCCTGTCCGGGTGCTGGGG
ACGGTGTTCTGTGATGCGTCGCAGTACCGTACTCAGGTAAAGGCCGCCATTGATTTCCTCATTGACGGCATTTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9087.15 Da
• Isoelectric Point: 6.4798

>AT111591 WP_062814467.1 NZ_CP032295:626806-627042 [Morganella morganii]
MTVKQRNTQSVTMTVERALLVRAREVGINLSATLTAALDAEVRHHEAKKWQEENRETIEALNRFHDEHGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT111591 NZ_CP032295:626806-627042 [Morganella morganii]
ATGACCGTGAAACAACGCAATACGCAGAGCGTGACCATGACGGTGGAACGCGCATTGCTGGTCCGGGCGCGTGAGGTTGG
TATTAACCTGAGTGCGACCCTGACCGCCGCCCTGGATGCAGAAGTTCGACACCATGAAGCAAAAAAATGGCAGGAAGAGA
ACAGAGAGACCATCGAAGCATTAAATCGTTTCCATGATGAACATGGCTGTTTCAGTGATGAATACCGGACATTTTAA