Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 352573..353161 Replicon plasmid pOXA58_010055
Accession NZ_CP032285
Organism Acinetobacter sp. WCHA55

Toxin (Protein)


Gene name brnT Uniprot ID N8SM64
Locus tag CDG62_RS02760 Protein ID WP_000438825.1
Coordinates 352874..353161 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID D3JXQ4
Locus tag CDG62_RS02755 Protein ID WP_004728120.1
Coordinates 352573..352887 (-) Length 105 a.a.

Genomic Context

CDG62_RS02750CDG62_RS02730CDG62_RS02735CDG62_RS02740CDG62_RS02745CDG62_RS02755CDG62_RS02760CDG62_RS02765CDG62_RS02770CDG62_RS02775CDG62_RS02780CDG62_RS02785
Location: 351954..352484 (531 bp)
Type: Others
Protein ID: WP_000172759.1
Location: 348313..349197 (885 bp)
Type: Others
Protein ID: WP_000155092.1
Location: 349253..350728 (1476 bp)
Type: Others
Protein ID: WP_000052512.1
Location: 351221..351502 (282 bp)
Type: Others
Protein ID: WP_000985609.1
Location: 351503..351805 (303 bp)
Type: Others
Protein ID: WP_000286964.1
Location: 352573..352887 (315 bp)
Type: Antitoxin
Protein ID: WP_004728120.1
Location: 352874..353161 (288 bp)
Type: Toxin
Protein ID: WP_000438825.1
Location: 353391..353996 (606 bp)
Type: Others
Protein ID: WP_000447788.1
Location: 354069..354682 (614 bp)
Type: Others
Protein ID: Protein_348
Location: 354745..355877 (1133 bp)
Type: Others
Protein ID: Protein_349
Location: 355968..356444 (477 bp)
Type: Others
Protein ID: Protein_350
Location: 356520..357347 (828 bp)
Type: Others
Protein ID: WP_000073658.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CDG62_RS02730348313..349197-885WP_000155092.1Mph(E) family macrolide 2'-phosphotransferase-
CDG62_RS02735349253..350728-1476WP_000052512.1ABC-F type ribosomal protection protein Msr(E)-
CDG62_RS02740351221..351502-282WP_000985609.1putative addiction module antidote protein-
CDG62_RS02745351503..351805-303WP_000286964.1type II toxin-antitoxin system RelE/ParE family toxin-
CDG62_RS02750351954..352484+531WP_000172759.1hypothetical protein-
CDG62_RS02755352573..352887-315WP_004728120.1BrnA antitoxin family proteinAntitoxin
CDG62_RS02760352874..353161-288WP_000438825.1BrnT family toxinToxin
CDG62_RS02765353391..353996-606WP_000447788.1LysE family translocator-
CDG62_RS02770354069..354682-614Protein_348IS4 family transposase-
CDG62_RS02775354745..355877-1133Protein_349IS3-like element ISAba14 family transposase-
CDG62_RS02780355968..356444-477Protein_350IS4-like element ISAba1 family transposase-
CDG62_RS02785356520..357347-828WP_000073658.1AraC family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidARR-3 / qacE / sul1 / blaPER-1 / aph(3')-VIa / cmlB1 / mph(E) / msr(E) / blaOXA-58-1..372328372328
-insideIScluster/Tnmph(E) / msr(E) / blaOXA-58-345092..36486219770


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11304.70 Da        Isoelectric Point: 5.6205

>T111589 WP_000438825.1 NZ_CP032285:c353161-352874 [Acinetobacter sp. WCHA55]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTDGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T111589 NZ_CP032285:c353161-352874 [Acinetobacter sp. WCHA55]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCGATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATACGAATCATTAGT
GCAAGGCAAGTGACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12200.86 Da        Isoelectric Point: 8.4628

>AT111589 WP_004728120.1 NZ_CP032285:c352887-352573 [Acinetobacter sp. WCHA55]
MSMVRYSRKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSSAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT111589 NZ_CP032285:c352887-352573 [Acinetobacter sp. WCHA55]
ATGAGCATGGTTAGATACTCACGCAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACCGATTGGAGCAGTGCTGTACGCC
AAAATCAATTTTACCGCCCAGTGAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGAATGAATGAAATTTTACGGGATGCTATGCTGAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0A8TVQ4

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0A8TRI9

References