Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 351221..351805 Replicon plasmid pOXA58_010055
Accession NZ_CP032285
Organism Acinetobacter sp. WCHA55

Toxin (Protein)


Gene name PumA Uniprot ID N8Q7V3
Locus tag CDG62_RS02745 Protein ID WP_000286964.1
Coordinates 351503..351805 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CDG62_RS02740 Protein ID WP_000985609.1
Coordinates 351221..351502 (-) Length 94 a.a.

Genomic Context

CDG62_RS02720CDG62_RS02725CDG62_RS02750CDG62_RS02730CDG62_RS02735CDG62_RS02740CDG62_RS02745CDG62_RS02755CDG62_RS02760CDG62_RS02765CDG62_RS02770CDG62_RS02775CDG62_RS02780
Location: 346310..346921 (612 bp)
Type: Others
Protein ID: WP_015060246.1
Location: 347162..348202 (1041 bp)
Type: Others
Protein ID: WP_087528923.1
Location: 351954..352484 (531 bp)
Type: Others
Protein ID: WP_000172759.1
Location: 348313..349197 (885 bp)
Type: Others
Protein ID: WP_000155092.1
Location: 349253..350728 (1476 bp)
Type: Others
Protein ID: WP_000052512.1
Location: 351221..351502 (282 bp)
Type: Antitoxin
Protein ID: WP_000985609.1
Location: 351503..351805 (303 bp)
Type: Toxin
Protein ID: WP_000286964.1
Location: 352573..352887 (315 bp)
Type: Others
Protein ID: WP_004728120.1
Location: 352874..353161 (288 bp)
Type: Others
Protein ID: WP_000438825.1
Location: 353391..353996 (606 bp)
Type: Others
Protein ID: WP_000447788.1
Location: 354069..354682 (614 bp)
Type: Others
Protein ID: Protein_348
Location: 354745..355877 (1133 bp)
Type: Others
Protein ID: Protein_349
Location: 355968..356444 (477 bp)
Type: Others
Protein ID: Protein_350
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CDG62_RS02720346310..346921+612WP_015060246.1recombinase family protein-
CDG62_RS02725347162..348202+1041WP_087528923.1IS481 family transposase-
CDG62_RS02730348313..349197-885WP_000155092.1Mph(E) family macrolide 2'-phosphotransferase-
CDG62_RS02735349253..350728-1476WP_000052512.1ABC-F type ribosomal protection protein Msr(E)-
CDG62_RS02740351221..351502-282WP_000985609.1putative addiction module antidote proteinAntitoxin
CDG62_RS02745351503..351805-303WP_000286964.1type II toxin-antitoxin system RelE/ParE family toxinToxin
CDG62_RS02750351954..352484+531WP_000172759.1hypothetical protein-
CDG62_RS02755352573..352887-315WP_004728120.1BrnA antitoxin family protein-
CDG62_RS02760352874..353161-288WP_000438825.1BrnT family toxin-
CDG62_RS02765353391..353996-606WP_000447788.1LysE family translocator-
CDG62_RS02770354069..354682-614Protein_348IS4 family transposase-
CDG62_RS02775354745..355877-1133Protein_349IS3-like element ISAba14 family transposase-
CDG62_RS02780355968..356444-477Protein_350IS4-like element ISAba1 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidARR-3 / qacE / sul1 / blaPER-1 / aph(3')-VIa / cmlB1 / mph(E) / msr(E) / blaOXA-58-1..372328372328
-insideIScluster/Tnmph(E) / msr(E) / blaOXA-58-345092..36486219770


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-90)

Antitoxin

Uncharacterized protein HI1420

(4-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11573.07 Da        Isoelectric Point: 4.6838

>T111588 WP_000286964.1 NZ_CP032285:c351805-351503 [Acinetobacter sp. WCHA55]
MYSIYTTEVFDDWFTKLKDQQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL

Download         Length: 303 bp

>T111588 NZ_CP032285:c351805-351503 [Acinetobacter sp. WCHA55]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTCACCAAGTTAAAAGACCAGCAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAGCCGGTCGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGGCCAGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTTGTTATTCTTTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTGCAATTGGCACAAGATTTAGAGGAGGAGCTATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10109.67 Da        Isoelectric Point: 8.0018

>AT111588 WP_000985609.1 NZ_CP032285:c351502-351221 [Acinetobacter sp. WCHA55]
MAIKLRKWDSAEHLKTEDDMQAYLQACIEESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI

Download         Length: 282 bp

>AT111588 NZ_CP032285:c351502-351221 [Acinetobacter sp. WCHA55]
ATGGCTATTAAACTTCGCAAATGGGACAGTGCTGAGCATCTTAAAACAGAGGATGATATGCAGGCTTACTTACAAGCATG
TATTGAAGAATCTAATGGCGATGCCGCATTCATTGCAAAGGCTTTAGGTAACATTGCAAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGCTTAGGCCGAGAAAGTCTTTATAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0A8TV94

Antitoxin

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Source
ID
Structure
No matching records found

References