Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-RelB
Location 4952..5465 Replicon plasmid p3_010055
Accession NZ_CP032282
Organism Acinetobacter sp. WCHA55

Toxin (Protein)


Gene name yoeB Uniprot ID N8YGB2
Locus tag CDG62_RS00565 Protein ID WP_000184943.1
Coordinates 4952..5215 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N8ZW56
Locus tag CDG62_RS00570 Protein ID WP_000557944.1
Coordinates 5202..5465 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDG62_RS00540 787..1074 - 288 WP_004870774.1 hypothetical protein -
CDG62_RS00545 1071..2012 - 942 WP_020846814.1 replication initiation protein -
CDG62_RS00555 2724..4376 - 1653 WP_004870770.1 MobA/MobL family protein -
CDG62_RS00560 4588..4890 + 303 WP_000110201.1 hypothetical protein -
CDG62_RS00565 4952..5215 - 264 WP_000184943.1 Txe/YoeB family addiction module toxin Toxin
CDG62_RS00570 5202..5465 - 264 WP_000557944.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CDG62_RS00575 5862..7430 + 1569 WP_087528895.1 ATP-binding cassette domain-containing protein -
CDG62_RS00585 7611..8936 + 1326 WP_020899627.1 ISNCY family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..14838 14838
- flank IS/Tn - - 20..685 665
- flank IS/Tn - - 7599..8936 1337


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10649.09 Da        Isoelectric Point: 8.4866

>T111587 WP_000184943.1 NZ_CP032282:c5215-4952 [Acinetobacter sp. WCHA55]
MTNRNVEWTDNAWDEYIYWQTQDKKILKRINTLIKECQRTPFEGTGKPEPLKANLSGFWSRRIDEKHRLVYEVTDERISI
IQCRFHY

Download         Length: 264 bp

>T111587 NZ_CP032282:c5215-4952 [Acinetobacter sp. WCHA55]
ATGACGAATCGTAACGTCGAATGGACTGATAATGCCTGGGATGAATATATCTATTGGCAGACACAGGATAAAAAGATACT
TAAGCGTATTAATACCTTAATCAAAGAATGTCAGCGAACACCTTTTGAAGGAACAGGAAAACCAGAACCTTTAAAAGCTA
ATCTTTCAGGATTTTGGAGTCGTAGGATTGATGAAAAGCATAGATTAGTTTATGAAGTGACAGATGAACGAATCTCTATA
ATTCAATGTCGATTCCATTACTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9834.99 Da        Isoelectric Point: 5.0829

>AT111587 WP_000557944.1 NZ_CP032282:c5465-5202 [Acinetobacter sp. WCHA55]
MHVFTYTDARNNLKSVLDKVIDDVDVAFITRKEGGHAVVMGQDHYDSLMETLYLLSSPNNASRLNESIAQLRAGKTKHRE
LIEDDES

Download         Length: 264 bp

>AT111587 NZ_CP032282:c5465-5202 [Acinetobacter sp. WCHA55]
ATGCATGTATTTACATATACGGACGCACGTAACAATTTAAAATCTGTTTTAGATAAAGTAATTGATGATGTAGACGTTGC
TTTTATTACAAGAAAAGAAGGTGGCCATGCTGTAGTAATGGGACAAGATCATTATGATAGCTTAATGGAAACGTTATATC
TCCTTTCATCTCCAAATAATGCAAGTCGTTTAAATGAATCAATTGCTCAATTACGTGCAGGGAAAACAAAACACAGAGAG
TTGATTGAGGATGACGAATCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C0XPS2

Antitoxin

Source ID Structure
AlphaFold DB A0A6C0XPU2

References