Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 5855..6432 Replicon plasmid p8_010034
Accession NZ_CP032276
Organism Acinetobacter sp. WCHAc010034

Toxin (Protein)


Gene name hicA Uniprot ID A0A3B7PRC3
Locus tag BEN74_RS00920 Protein ID WP_068912612.1
Coordinates 6184..6432 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A3B7PTX8
Locus tag BEN74_RS00915 Protein ID WP_068912614.1
Coordinates 5855..6187 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BEN74_RS00890 1499..2524 + 1026 WP_068912620.1 replication initiation protein -
BEN74_RS00895 2764..3249 + 486 WP_068912619.1 plasmid mobilization relaxosome protein MobC -
BEN74_RS19180 3239..5755 + 2517 WP_068912617.1 mobilization protein -
BEN74_RS00915 5855..6187 - 333 WP_068912614.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BEN74_RS00920 6184..6432 - 249 WP_068912612.1 type II toxin-antitoxin system HicA family toxin Toxin
BEN74_RS00925 6571..7317 - 747 WP_068912609.1 hypothetical protein -
BEN74_RS00930 7407..7739 + 333 WP_017397197.1 hypothetical protein -
BEN74_RS00935 7763..8044 - 282 WP_068912607.1 putative addiction module antidote protein -
BEN74_RS00940 8045..8347 - 303 WP_068912604.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..8540 8540


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-78)

Antitoxin

Uncharacterised protein family HicB

(54-101)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9516.16 Da        Isoelectric Point: 10.5293

>T111584 WP_068912612.1 NZ_CP032276:c6432-6184 [Acinetobacter sp. WCHAc010034]
MGKTEKLLERFGNAKNTFPYKDLVVLLNQLGYEKFEMAGSRVRFFNAKTEHMILLHRPHPENEIKGGALKAVKQALKQER
FL

Download         Length: 249 bp

>T111584 NZ_CP032276:c6432-6184 [Acinetobacter sp. WCHAc010034]
ATGGGTAAAACGGAAAAGTTACTAGAAAGATTCGGAAATGCAAAAAATACATTTCCGTATAAGGATTTAGTCGTTTTACT
GAATCAGCTCGGCTATGAAAAGTTTGAAATGGCAGGCTCTCGTGTCCGTTTTTTTAATGCAAAAACTGAACACATGATTT
TACTGCACAGGCCACATCCTGAAAATGAAATCAAAGGTGGAGCATTGAAAGCTGTGAAACAGGCACTCAAGCAGGAGAGA
TTTTTATGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12316.06 Da        Isoelectric Point: 4.8951

>AT111584 WP_068912614.1 NZ_CP032276:c6187-5855 [Acinetobacter sp. WCHAc010034]
MSYLKYKGYLGTIEPDLETGELFGKLAFIRDLITYEAETLKALEQAFKESVDGYLESCTELGKNPDQPFKGTFNVRISPE
MHRKAVLASSNSLNSFVSDAIQEKLMRLGA

Download         Length: 333 bp

>AT111584 NZ_CP032276:c6187-5855 [Acinetobacter sp. WCHAc010034]
ATGAGCTACTTAAAATACAAAGGCTATCTTGGTACGATTGAACCTGATCTCGAAACAGGCGAATTGTTTGGAAAACTTGC
GTTTATCCGTGATCTCATCACCTATGAAGCAGAAACATTAAAAGCACTTGAGCAAGCTTTTAAAGAATCTGTAGATGGCT
ATTTAGAATCTTGTACTGAACTAGGTAAAAACCCTGATCAGCCATTTAAAGGCACGTTTAATGTGCGTATTAGCCCTGAA
ATGCACCGTAAAGCTGTTTTAGCATCAAGTAATTCTCTTAACTCCTTTGTCAGTGATGCGATTCAAGAAAAATTAATGCG
TTTAGGTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3B7PRC3

Antitoxin

Source ID Structure
AlphaFold DB A0A3B7PTX8

References