Detailed information of TA system TA111580

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 38464..38974
• Replicon: plasmid p1_010034
• Accession: NZ_CP032268
• Organism: Acinetobacter sp. WCHAc010034

Toxin (Protein)

• Gene name: relB
• Uniprot ID: N9QHP6
• Locus tag: BEN74_RS00255
• Protein ID: WP_005264103.1
• Coordinates: 38464..38727 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: N9Q7E5
• Locus tag: BEN74_RS00260
• Protein ID: WP_005264105.1
• Coordinates: 38711..38974 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BEN74_RS00230	33802..34062	+	261	WP_004665962.1	ferrous iron transport protein A	-
BEN74_RS00235	34052..35881	+	1830	WP_068911058.1	ferrous iron transporter B	-
BEN74_RS00240	36003..36959	-	957	WP_004665958.1	arsenic resistance protein	-
BEN74_RS00245	36970..37536	-	567	WP_004758168.1	recombinase family protein	-
BEN74_RS00250	38092..38427	+	336	WP_068911057.1	hypothetical protein	-
BEN74_RS00255	38464..38727	-	264	WP_005264103.1	Txe/YoeB family addiction module toxin	Toxin
BEN74_RS00260	38711..38974	-	264	WP_005264105.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
BEN74_RS19565	39145..39283	+	139	Protein_48	IS6 family transposase	-
BEN74_RS00265	39491..39724	+	234	WP_005264115.1	hypothetical protein	-
BEN74_RS00270	39727..40275	+	549	WP_005264116.1	hypothetical protein	-
BEN74_RS00280	40496..41008	+	513	WP_068911055.1	AAA family ATPase	-
BEN74_RS00285	41036..41968	+	933	WP_068907481.1	IS5 family transposase	-
BEN74_RS00295	42360..43292	-	933	WP_068907481.1	IS5 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..66814	66814

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10288.79 Da
• Isoelectric Point: 9.0098

>T111580 WP_005264103.1 NZ_CP032268:c38727-38464 [Acinetobacter sp. WCHAc010034]
MKRKTSFTPSAWDDYVYWQSQDKKTLKRINALIKECLRTPFEGIGKPEPLLGDLSGFWSRRIDEKNRLVYEVTDAAITII
SCRYHYE

Nucleotide

• Length: 264 bp

>T111580 NZ_CP032268:c38727-38464 [Acinetobacter sp. WCHAc010034]
ATGAAACGGAAGACTAGTTTTACACCTTCAGCTTGGGATGATTATGTTTACTGGCAAAGCCAAGACAAAAAGACTCTAAA
GCGAATCAATGCCTTAATCAAGGAGTGTCTGAGAACTCCATTTGAAGGTATTGGTAAGCCTGAACCATTACTCGGTGATT
TATCTGGGTTTTGGAGCAGACGAATAGATGAAAAGAATAGACTAGTCTATGAAGTAACAGACGCAGCGATAACGATTATT
TCATGTCGTTACCACTACGAATGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9806.00 Da
• Isoelectric Point: 4.6365

>AT111580 WP_005264105.1 NZ_CP032268:c38974-38711 [Acinetobacter sp. WCHAc010034]
MHVFTYTDARNNLKTVLDRVIDDADVAVITRKEGQHAVVMGQDYYDSLMETLHLMSSPSNAAHLAKSIAELRASKTIERE
LLDETED

Nucleotide

• Length: 264 bp

>AT111580 NZ_CP032268:c38974-38711 [Acinetobacter sp. WCHAc010034]
ATGCATGTATTTACATATACAGATGCTCGCAATAACCTGAAAACGGTTTTAGACCGTGTTATTGATGATGCAGATGTAGC
TGTTATTACACGTAAAGAAGGTCAACATGCCGTTGTTATGGGTCAAGACTATTACGATAGTTTGATGGAAACATTGCATC
TCATGTCTTCTCCAAGTAATGCAGCACATTTAGCAAAATCAATTGCAGAATTACGAGCATCTAAAACGATCGAAAGAGAA
CTTTTAGATGAAACGGAAGACTAG

Structures

Toxin

• AlphaFold DB: N9QHP6

Antitoxin

• AlphaFold DB: N9Q7E5