Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4042362..4043193 Replicon chromosome
Accession NZ_CP032265
Organism Escherichia coli strain AR_0089

Toxin (Protein)


Gene name yeeV Uniprot ID A0A768PNB2
Locus tag AM468_RS21910 Protein ID WP_061157912.1
Coordinates 4042362..4042736 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A785EPM7
Locus tag AM468_RS21915 Protein ID WP_001535568.1
Coordinates 4042825..4043193 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM468_RS21870 4037758..4038924 + 1167 WP_061157914.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
AM468_RS21875 4039043..4039516 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
AM468_RS21880 4039714..4040772 + 1059 WP_001200890.1 FUSC family protein -
AM468_RS21885 4040944..4041273 + 330 WP_000450409.1 DUF496 family protein -
AM468_RS21890 4041374..4041556 - 183 WP_061157913.1 ethanolamine utilization protein -
AM468_RS21895 4041610..4041756 + 147 Protein_3759 transposase domain-containing protein -
AM468_RS21900 4042045..4042158 - 114 WP_001161660.1 DUF957 domain-containing protein -
AM468_RS21905 4042171..4042365 - 195 WP_000988601.1 hypothetical protein -
AM468_RS21910 4042362..4042736 - 375 WP_061157912.1 type IV toxin-antitoxin system toxin CbtA Toxin
AM468_RS21915 4042825..4043193 - 369 WP_001535568.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
AM468_RS21920 4043267..4043488 - 222 WP_061157911.1 DUF987 domain-containing protein -
AM468_RS21925 4043551..4044027 - 477 WP_001186786.1 RadC family protein -
AM468_RS21930 4044043..4044522 - 480 WP_061157910.1 antirestriction protein -
AM468_RS21935 4044785..4045606 - 822 WP_001234571.1 DUF945 domain-containing protein -
AM468_RS21945 4045827..4046237 - 411 WP_061157909.1 hypothetical protein -
AM468_RS21950 4046253..4046930 - 678 WP_001362823.1 hypothetical protein -
AM468_RS21955 4047066..4048136 - 1071 WP_061157908.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13871.91 Da        Isoelectric Point: 7.8522

>T111570 WP_061157912.1 NZ_CP032265:c4042736-4042362 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNSITLGKYPEAK

Download         Length: 375 bp

>T111570 NZ_CP032265:c4042736-4042362 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAGCATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13481.26 Da        Isoelectric Point: 5.0468

>AT111570 WP_001535568.1 NZ_CP032265:c4043193-4042825 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLSSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLACEADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT111570 NZ_CP032265:c4043193-4042825 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
CCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCAATCAGCATACCGTCACGCTGTATGCGAAGGGGCTGGCCTGTGAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A768PNB2

Antitoxin

Source ID Structure
AlphaFold DB A0A785EPM7

References