Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2864602..2865437 Replicon chromosome
Accession NZ_CP032265
Organism Escherichia coli strain AR_0089

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7A2ZCB4
Locus tag AM468_RS16020 Protein ID WP_061157978.1
Coordinates 2864602..2864979 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MK11
Locus tag AM468_RS16025 Protein ID WP_001285610.1
Coordinates 2865069..2865437 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM468_RS15990 2859730..2860878 - 1149 WP_000905922.1 capsule polysaccharide export inner-membrane protein KpsE -
AM468_RS15995 2860950..2861933 - 984 WP_061157979.1 KpsF/GutQ family sugar-phosphate isomerase -
AM468_RS16000 2862744..2862914 - 171 Protein_2661 IS110 family transposase -
AM468_RS16005 2863256..2864098 - 843 WP_001280493.1 DUF4942 domain-containing protein -
AM468_RS16010 2864183..2864380 - 198 WP_085949090.1 DUF957 domain-containing protein -
AM468_RS16015 2864408..2864605 - 198 Protein_2664 hypothetical protein -
AM468_RS16020 2864602..2864979 - 378 WP_061157978.1 type IV toxin-antitoxin system toxin CbtA Toxin
AM468_RS16025 2865069..2865437 - 369 WP_001285610.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AM468_RS16030 2865517..2865738 - 222 WP_000692350.1 DUF987 domain-containing protein -
AM468_RS16035 2865825..2866301 - 477 WP_001186774.1 RadC family protein -
AM468_RS16040 2866317..2866802 - 486 WP_061157977.1 antirestriction protein -
AM468_RS16045 2866894..2867712 - 819 WP_061157976.1 DUF945 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element sul2 / tet(B) / aph(3')-Ia / aph(6)-Id / aph(3'')-Ib rfaE / gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM / kpsM / kpsT / neuD / neuB / neuA / neuC / neuE / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF / papC / papD / papI / papB / papA / papH / papC / papD / papJ / papK / papE / papF / papG 2731064..2969209 238145


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(19-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 13911.90 Da        Isoelectric Point: 7.9085

>T111566 WP_061157978.1 NZ_CP032265:c2864979-2864602 [Escherichia coli]
MKTLPVLPGQAASSHPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T111566 NZ_CP032265:c2864979-2864602 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACACCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13606.39 Da        Isoelectric Point: 6.0618

>AT111566 WP_001285610.1 NZ_CP032265:c2865437-2865069 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT111566 NZ_CP032265:c2865437-2865069 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7A2ZCB4


Antitoxin

Source ID Structure

References